Of tumor invasion and metastasis KU-0063794 perfect. Gb3 is confinement in several human cancers Lich expressed breast cancer and testicular cancer. Expression was detected in Gb3 lymphomas and solid tumors. Gb3 expression of colorectal cancer is correlated with invasive and metastatic potential. High levels of Gb3 were observed also proposed in resistant cancers and cell lines and functional interaction between membrane Gb3 and MDR1 was. These results suggest that the Bindungsspezifit t Gb3 VT used 1 k Nnte To tumors in cancer cells received Nglicher targeting. Third Multidrug resistance in cancer chemotherapy poor response to chemotherapy is usually due to drug resistance. In breast cancer alone, nearly 50 patients have prime Acids or secondary Ren resistance to doxorubicin.
Tumors overexpress SP600125 membrane glycoprotein efflux transporter P is a joint selling Change resistance. P gp, is encoded by the MDR1 gene, the first protein ABC is resistance to chemotherapeutic agents shown to confer cancer. Other transport proteins Such as protein and multidrug resistance protein in breast cancer have also been described. P gp plays an r In the absorption, distribution and excretion of compounds in normal tissues. MDR1 overexpression in tumors leads active efflux of several types of anti-cancer agents. C P gp is of many types of solid tumors such as primary Re chest Lon, kidney and ovarian and malignant h Dermatological diseases such as leukemia Anemia, myeloma expressed With acute and non-Hodgkin’s lymphoma. Exposure to chemotherapy to the tumor k Can regulate P gp expression that occurs in the acquired drug resistance and obliquely about.
Limited the success of chemotherapy. In lung cancer, small cell acquired resistance to multiple drugs is responsible for a chemotherapeutic cure rates below 10 In breast cancer, 55 tumors expressed P gp 55 before and 100 after chemotherapy. MDR1 inhibitors tested clinically to block the flow of drugs. Modulators or specific inhibitors such as LY335979 and GG918 were overcome the undesirable toxic effects observed in the first generation of modulators, but also a small effect when together with chemotherapeutic agents in tests administered portion. Because MDR1 polymorphisms 4th Globotriasosylceramide and MDR1 expression is Conna Little t the molecular mechanisms MDR1 overexpression and how it interacts with other genes to confer resistance to drugs.
Overexpression of glucosylceramide synthase, the first enzyme entered in GSL synthesis dinner multidrug resistance. Many cells show high MDR1 inhibitors of glucosylceramide and GCS t Th MDR cells. MDR1 translocation can glucosylceramide in the Golgi apparatus in the neutral GSL synthesis confinement, Lich Gb3. P was as gp Golgi glucosylceramide flippase increases neutral GSL synthesis have been proposed as transfection of MDR1 increases, and reduces the inhibition of P gp neutral GSL biosynthesis in cells. Regulate GCS