94% respectively after XE stages. The release of reducing sugars and chromophores was highest for both the enzymes at 10 IUg and reaction time 180 min for 55 degrees C at variable consistencies that is, 10% click here for enzyme-A and 5% for enzyme-B. (A)XECEHH and (B)XECEHH sequences improved brightness by 5.17 and 2.58% respectively at 4.5% chlorine charge. AOX in (A)XECEHH and (B)XECEHH sequences reduced by 56.11 and 55.75% respectively at 4.5% chlorine charge and 68.34 and 67.98% respectively at 2.25% chlorine
charge respectively compared to control. Both the enzymes showed improvement in double fold and tear index with a decrease in burst and tensile index. SEM showed peeling, cracking and delamination in fibers due to enzyme treatment thus facilitating the penetration of bleach chemicals.”
“B-cell chronic lymphocytic leukemia (CLL) is characterized by slow accumulation of malignant cells, which are supported in the microenvironment by cell-cell interactions and soluble cytokines such as tumor necrosis factor (TNF). We evaluated the effect of the small molecule TNF inhibitor LMP-420 on primary CLL cells. The mean concentration of LMP-420 required to induce 50% cytotoxicity (ED50) at 72 h was 245 nM. LMP-420-induced time- and dose-dependent apoptosis, as shown by annexin V staining, caspase activation and DNA fragmentation. These changes were associated with decreased
expression of anti-apoptotic proteins Mcl-1, Bcl-xL and Bcl-2. CLL cells GSK3326595 from patients with poor prognostic indicators showed LMP-420
sensitivity equal to that for cells from patients with favorable characteristics. In addition, LMP-420 potentiated the cytotoxic effect of fludarabine and inhibited in vitro proliferation of stimulated CLL cells. Gene expression profiling indicated that the mechanism of action of LMP-420 may involve suppression of nuclear factor-kappa B and immune response pathways in CLL cells. LMP-420 had minimal effects on normal peripheral blood mononuclear cell, B-and T-cell function, and hematopoietic colony formation. Our data suggest that LMP-420 Non-specific serine/threonine protein kinase may be a useful treatment for CLL with negligible hematologic toxicities. Leukemia (2010) 24, 1580-1587; doi:10.1038/leu.2010.150; published online 8 July 2010″
“Pretreatment of wheat straw pulp using cellulase-free xylanase produced from Bacillus stearothermophilus SDX at 60 degrees C for 120 min resulted in 4.75% and 22.31% increase in brightness and whiteness, respectively. Enzyme dose of 10 U/g of oven dried pulp at pH 9 decreased the kappa number and permanganate number by 7.14% and 5.31%, respectively. Further chlorine dioxide and alkaline bleaching sequences (CDED(1)D(2)) resulted in 1.76% and 3.63% increase in brightness and whiteness, respectively. Enzymatic prebleaching of pulp decreased 20% of chlorine consumption without any decrease in brightness.