For subjects NU7026 chemical structure aged 65 years and above, the incidence for all fractures was 839/100,000 person-years, for non-spine fractures was 769/100,000 person-years and for hip fracture was 201/100,000 person-years. In terms of individual risk factors, history of fall and history of fragility fracture were associated with the highest predicted 10-year risk of fracture: the relative risk was 14.5 (95% CI 6.5–32.2) and 4.4 (95% CI 2.0–9.4), VX-661 cost respectively. Although a 10-year increase in age accounted for only a 5.8% increase in 10-year osteoporotic fracture risk, older men aged 65 years or above had a 2.7-fold higher risk of fracture compared with

younger men. Figure 1 shows the fracture risk in different age groups that was adjusted for competing risk of death along the study period. Men aged 65 years or older with one or more falls per year had a 10-year risk of fracture of 31.9% compared with oxyclozanide 15.8% for those younger than 65 years old. Table 2 Clinical risk factors associated with osteoporotic IWP-2 clinical trial fracture in Hong Kong Southern Chinese men (n = 1,810) Risk factors Subjects (%) B RR (95%

CI) P Age ≥ 65 years 1148 (63.4) 1.0 2.7 (1.2–5.8) 0.013 Age per 10 years increase   0.1 1.1 (1.0–1.1) 0.003 Grip strength <30 kg 447 (24.7) 1.2 3.3 (0.6–17.2) 0.160 History of fall within 1 year 257 (14.2) 2.7 14.5 (6.5–32.3) <0.0001 Difficulty bending forward 185 (10.2) 1.3 3.6 (1.3–9.9) 0.014 Kyphosis 78 (4.3) 1.2 3.4 (0.8–14.8) 0.100 Low back pain 510 (28.2) −0.1 0.9 (0.4–2.2) 0.895 BMI < 20 kg/m2 167 (9.2) 1.3 3.6 (1.0–12.8) 0.050 BMI per unit increase   −0.1 0.9 (0.8–0.9) <0.0001 Walking <30 min/day 167 (9.2) 0.5 1.6 (0.5–5.4) 0.457 History of fragility fracture 576 (31.8) 1.5 4.4 (2.0–9.4) <0.0001 History of clinical or morphometric spine fracture 112 (6.2) −0.3 0.7 (0.1–6.0) 0.761 History of clinical spine fracture 52 (2.9) 0.5 1.6 (0.2–12.0) 0.635 History of parental fracture 65 (3.6) −0.3 0.8 (0.1–5.7) 0.799 Use of walking aid 264 (14.6) 1.0 2.7 (1.1–6.5) 0.030 Homebound 121 (6.7) −0.5 0.6 (0.1–4.5) 0.620 Outdoor activity <60 min/day 608 (33.6) 1.4 4.1 (1.7–9.9) 0.001 Current and ever smoking 673 (37.2) 0.5 1.7 (0.8–3.5) 0.135 Current and ever drinking 43 (2.4) 1.0 2.7 (0.4–20.4) 0.326 Calcium Intake <400 mg/day 185 (10.2) 0.2 1.