We submitted a concept using Caravaggio’s dark painting of a beheaded and bloody Medusa, with a decidedly shocked look on its face, upon which we superimposed a lynx image. Neuron loved this submission, but some of us, Nat [Heintz] in particular, did not like the aesthetics of that ghastly image as our cover. What were we to do? My cousin Susan Moriguchi, a graphic designer, came to the rescue and switched to a sculptural image of Medusa that retained the concept with much more grace and symmetry than our efforts. A cover was born,

and to this day, the idea of a toxin-like modulator remains a puzzling dialectic— is it a friend (protects neurons) or foe (suppresses plasticity http://www.selleckchem.com/products/obeticholic-acid.html and learning)? —Julie Miwa Figure options Download full-size image Download high-quality image (39 K) Download as PowerPoint slideIt started with “Cookie, I have a great idea!” Whether it was myelination or synapse adhesion, David Colman visualized dynamic cell biological processes in real time and in three dimensions. So keen was he to convey his vision of how things worked that he had a full-time

artist, Jill Gregory, as part of his group. Ever eager to push the boundaries of convention, it was Jill (a.k.a. Cookie) to whom he first turned when he realized that a hologram was the perfect unconventional way mTOR inhibitor to convey his vision of the organization of synapses. It was the dawning of a new century and what better way to make an impact than with a synapse hologram for a cover? As the lab put the final touches on the paper, Dave and Jill made trips to Connecticut to see the hologram team and meet with Neuron editors to ensure that the cover could be printed and reprinted. The final result was fantastic, something that Dave and those who worked closely with him were very proud of. It achieved exactly what Dave had hoped for: it sparked discussions and stimulated new ideas. It remains a beautiful work

of art and science and a fitting tribute to David [who passed away in 2011]. —Deanna Benson Figure options Download full-size image Download high-quality image (110 K) Download as PowerPoint slide !!!FRAG!!! Resminostat When ambling my way to lab, I’d take in as much light as I could, knowing that I’d spend the rest of the day in complete dark imaging dendrites’ twisted and unpredictable branches, searching for calcium signals that would bring them to life. These dendrites really got into my head—I’d see them in my sleep, I’d see them in the trees, I’d see them in the wrinkles on people’s faces, on cracks in the sidewalk. For the cover, I wanted to capture this universality of dendrite structure, but also the obviousness, if you will, that local processing is an essential part of that complex structure. When I made the cover, I hunted throughout the city and found the most stunning red tree in the Ramble, a tree-filled labyrinth in Central Park.