Aim was to find out the causes of hospital mortality in patients admitted with decompensated cirrhosis and to evaluate for the biochemical and hematological

parameters that are related to mortality during hospitalization RXDX-106 chemical structure Methods: Cirrhotic patients admitted at the Department of Gastroenterology at Govt Stanley Medical College from April 2010 to may 2011 were studied. Patients with decompensated cirrhosis liver who died during admission were selected as cases. Patients admitted with cirrhosis and its complications and who improved with treatment followed by discharge were selected as controls. Data collected included demographics; etiology of cirrhosis; indication for hospital admission; presence or absence of decompensation buy FK506 and portal hypertension; and the corresponding Child Pugh, MELD, and MELD-Na scores. Other hematological and biochemical markers were studied. The clinical diagnosis of cirrhosis was made by a history of portal hypertension excluding other etiology, liver function tests, clotting parameters, radiology criteria. The cause of death was also determined. Exclusion criteria were patients with portal hypertension not due to primary cirrhosis of liver cirrhosis complicated by hepatocellular carcinoma were excluded. Ethical committee approval was obtained for the study. Results: Total

number of cases was 140 (70 each for cases and controls). The Mean age was 46.33 years and 45.56 for controls. The mean duration of disease in cases was 20.01 months and 12.76 months for controls. The most common cause was ethanol related. The number of hepatic and non hepatic complications in both groups was similar and most patients had 2 or more comorbid conditions. The most common cause of admission was hepatic encephalopathy in both groups. While evaluating for Child status in selleck kinase inhibitor both groups, 11.4 % of patients

in both groups had Child’s A. 48.6% of cases had Child’ s B while 52.9% of controls had Child’s B. 40.0% cases and 35.7% controls had Child’s C cirrhosis. The mean MELD and MELD-Na was significantly ( < 0.001) higher for the cases group compared to the control group. The most common causes of death are due to cirrhosis related complications associated with decompensation like hepatic encephalopathy, hepatorenal syndrome, UGI bleeding and infections. On univariate analysis revealed that increasing levels of MELD, MELD- Na, serum creatinine, INR, WBC, albumin, neutrophilia and duration of disease were significantly ( < 0.0001) associated with increased risk of death. On multivariate forward stepwise logistic regression, an elevated WBC count (p = 0.02, OR 1.2) and creatinine (p = 0.003, OR 1.2) were the only factors significantly associated with death. Conclusion: In hospital mortality in cirrhosis is predominantly due to hepatic dysfunction.