l.) and open-loop (o.l.) and irregular (IV) type (c.l. and o.l.). S-pattern: regular (RS – oval, tubular, villous), irregular (IS) and absent (AS). Biopsies were taken for histological assessment. Results: 8 of 20 possible V- and S-pattern combinations were defined; the rest of them were not identified in the present study. The results are summarized in the table. Three cancer risk groups were distinguished: low (RV + RS), moderate (RV (o.l.) + IS and IV + IS) and high (IV + AS). Conclusion: Cancer risk assessment system could be the basis of computer-aided analysis of endoscopic magnifying MLN2238 images for effective cancer risk prediction of gastric lesions. Key Word(s): 1.
magnification; 2. NBI; 3. h. pylori gastritis; 4. computer-aided; Presenting Author: SERGEY KASHIN Additional Authors: ROMAN KUVAEV, ALEXANDER NADEZHIN, ANDREY NECHIPAI, IGOR IVANIKOV, EVGENY NIKONOV, NIKOLAY AKHAPKIN Corresponding Author: SERGEY KASHIN Affiliations: Yaroslavl Regional Cancer Hospital; Russian Academy of Postgraduate Medical Education; Central Clinical Hospital with Polyclinic of the Business Administration for the President of the Russian Federation; Polyclinic №1 of the Business Administration for the President of the Russian Federation Objective: “Red flag” techniques,
such as AFI and indigocarmine chromoendoscopy (CE), are imaging technologies that allow scanning a wide area of mucosa for detecting suspect lesions. However the optimal “red flag” method hasn’t been established yet. The Dichloromethane dehalogenase aim was to determine the efficacy of AFI and CE in detection of gastric lesions. Methods: This study comprised 68 lesions in 51 patients (pts). Initially all pts was investigated CHIR-99021 datasheet by standard endoscopy combined with CE (Olympus Exera II GIF H180). Afterwards these pts was examined by AFI (Olympus Lucera GIF-FQ 260Z). Finally all detected lesions were observed by using narrow-band imaging and high-magnification endoscopy – NBI-HME (Olympus Lucera GIF-FQ 260Z). AFI–positive lesions divided to purple in green (P/G) and green in purple (G/P). Irregular microvascular pattern (IMVP) with irregular (IMSP) or absence (AMSP) microstructure pattern was used as the criterion of neoplasia. Biopsies were taken
from all lesions for histological assessment. Results: From 68 detected lesions there were 65 AFI-positive lesions (53 (81.54%) P/G-pattern and 12 (18.46%) G/P-pattern) and 3 AFI-negative lesions (2 neoplastic, 1 nonneoplastic) detected with only WLE with CE. P/G-pattern included 25 (47.17%) nonneoplastic (chronic gastritis, intestinal metaplasia, hyperplasia) and 28 (52.83%) neoplastic (LGD, HGD, adenocarcinoma, ring-cell cancer) lesions (n.s.). G/P-pattern included 5 (41.67%) nonneoplastic and 7 (58.33%) neoplastic lesions (n.s.). In all detected lesions IMSP/AMSP with IMVP were found in 20 cases (19 neoplastic and 1 nonneopastic lesions). Conclusion: Both AFI and CE demonstrated high sensitivity (94.87% and 97.36% respectively) but low specificity (both 50.82%).