Penetration gefitinib, an inhibitor of epidermal growth element tyrosine kinase. Mol Cancer Ther. 2005, four:641 649th Menard S, Pupa SM, Campiglio M, Tagliabue E. HER2 r biological and therapeutic for cancer. Oncogene. 2003, 22:6570 6578th Messerle K, Schlegel J, Hynes NE, Gr, D Dinner NIH/3T3 cells with erbB 2 oncogene by activated kinase Notypisch transformed ph lack returned dominant bad erbB Nutlin-3 price variant 2 Mol Cell Endocrinol. 1994, 10 105:1. Miknis G, Wallace E, Lyssikatos J, Lee P, Q Zhao, Hans J., et al. ARRY 334543, a potent and orally energetic smaller molecule EGFR 2nd Proc Am Assoc erbB Can Res 2005, 24 # 3399th MM The oncogene HER2 signaling Moasser and converting functions, and r from the pathogenesis of human cancer. Oncogene. 2007, 26:6469 6487th Moasser MM, Basso A, Averbuch SD, Rosen N.
The tyrosine kinase inhibitor ZD1839 inhibits HER2 signaling are born and inhibits the development of tumor cells overexpressing HER2. Cancer Research. 2001, 61:7184 7188th Mohsin SK, Weiss HL, Gutierrez MC, Chamness GC, XL147 Boot R, DiGiovanna MP, et al. Neoadjuvant trastuzumab induces apoptosis in primary Ren Ren breast cancer. J Clin Oncol. 2005, Molina MA 23:2460 2468th Codony Servat J, J Albanell, Rojo C, Arribas J, Baselga J. Trastuzumab, a humanized anti-HER2 receiver singer K Rpers inhibits Her2 monoclonal you Ektodom base cleavage and breast cancer cells activated. Cancer Res 2001, 61:4744 4749th Molina MA, Saez R, Ramsey EE, Garcia Barchino MJ, Rojo F, Evans AJ, et al. NH terminally truncated protein HER 2, but not receptor-associated L complete l length With lymph node metastasis in human breast cancer cells.
Clin Cancer Res 2002, 8:347 353rd Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero CP, Sterner CJ, et al. Repressor Snail promotes f F breast tumor recurrence. Cancer Cell. 2005, eight:197 209th Moody SE, Sarkisian CJ, Hahn KT, Gunther EJ, Pickup S, Dugan KD, et al. New conditional activation in mammary epithelium of transgenic M nozzles benefits in reversible pulmonary metastasis. Cancer Cell. 2002, 2:451 461st Moulder SL, yakes FM, Muthuswamy SK, Bianco R, Simpson JF, Arteaga CL. epidermal development factor receptor tyrosine kinase inhibitor ZD1839 inhibited HER2/neu overexpressing breast cancer in vitro and in vivo. Cancer Analysis. 2001, 61:8887 8895th Moyer JD, Barbacci EG, Iwata KK, Arnold L, Boman B, Cunningham et al.
Induction of apoptosis and cell cycle by CP 358 774, a kinase inhibitor of your epidermal growth element receptor-tyrosine. Cancer Res 1997, 57:4838 4848th Nagata Y Lan KH, Zhou X, Tan M, Esteva FJ, Sahin AA, et al. Gt PTEN activation tr tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in people. Cancer Cell. 2004, 6:117 127th Naito K, Matsutani E, Tamura T, Miwa K, Takakura N, Asada M, Tasaka A, Miyake A, Z. Terashita TAK-165, a selective inhibitor on the tyrosine kinase HER2 one gt from the nature in the inhibition of tyrosine kinase and selective anti -tumor activity of t in vivo and in vitro T. Proc Am Assoc Can Res 2002, 43 # 3897. RM Neve, UB Nielsen, DB Kirpotin, Poul MA, Marks JD, Benz CC. Biological effects of anti-ErbB2 cha outdated K Body to determine, not only so as to internalize the function. Biochem Biophys Res Commun. 2001, 280:274 279th Norman N, Campiglio M, De LA some