The lung lesions that ensued were then examined macro-and microscopically. The same procedures were repeated at a distance of 1 cm creating parallel lesions in
order to analyse the lung tissue in between the lesions for thermal damage. In addition, two implanted capsules in the lung tissue simulating a lung nodule were resected with either the laser or the monopolar cutter. The resection surfaces were then examined by magnetic resonance imaging and histology for tissue damage. Finally, we created a 2-cm wide mark on the lung surface to test the resection capacity of both instruments within Danusertib ic50 1 min.
RESULTS: The laser created sharply delineated lesions with a vaporization and coagulation www.selleckchem.com/products/BMS-777607.html zone without thermal damage of the surrounding lung tissue. With lowering the working speed, each zone was extended. At a working speed of 10 mm/s, the mean vaporization depth using the laser was 1.74 +/- 0.1 mm and the mean coagulation depth was 1.55 +/- 0.09 mm. At the same working speed, the monopolar cutter demonstrated a greater cutting effect (mean vaporization
depth 2.7 +/- 0.11 mm; P < 0.001) without leaving much coagulation on the resection surface (mean coagulation depth 1.25 +/- 0.1 mm; P = 0.002). In contrast to the laser, the monopolar cutter caused thermal damage of the adjacent lung tissue. The adjacent tissue injury was detected in histological examination as well as in the MRI findings. Adjacent lung tissue after lung metastasectomy using the monopolar cutter
was hyper-intensive in T-2-weighted MR imaging, indicating a severe tissue damage. No significant changes in signal intensity were observed in T-2-weighted imaging of the adjacent Nepicastat supplier lung tissue after using the laser for lung resection. One minute of laser applied at a 100-watt output penetrated a lung surface area of 3.8 +/- 0.4 cm(2) compared with 4.8 +/- 0.6 cm(2) of surface after application of the monopolar cutter (P = 0.001).
CONCLUSIONS: The monopolar cutter possesses indeed a greater cutting capacity than the laser, but it also causes more adjacent tissue injury. Thus, laser resection might be preferred for lung metastasectomy.”
“Objectives: Periventricular leukomalacia (PVL) is the predominant form of brain injury in premature infants, and no specific treatment currently exists for this condition. We have evaluated whether maternal omega-3 fatty acid (omega 3 FA) treatment reduces endotoxin-induced PVL in the developing rat brain. Methods: Wistar rats with dated pregnancies were fed a standard diet or a diet enriched in omega 3 FA (70% docosahexaenoic acid + 30% eicosapentaenoic acid mixture) during gestation. Intraperitoneal injection of lipopolysaccharide (LPS) was administered consecutively on the 18th and 19th embryonic days to establish the endotoxin-induced PVL rat model.