[1] The histological finding of the present case consists of a well-defined fibrous capsule having two patterns. Antoni ��A�� areas are composed of compact spindle-shaped cells with twisted Tofacitinib Citrate nuclei, indistinct cytoplasmic borders and occasional clear intranuclear vacuoles arranged in bundles or inter lacing fascicles.[5] In the Antoni ��A�� areas there was nuclear palisading, whirling of cells and Verocay bodies formed by two compact rows of well aligned nuclei separated by fibrillar cell processes. Antoni ��B�� areas were far less orderly and cellular. The spindle or oval cells were arranged haphazardly in the loose textured matrix, which was punctuated by microcystic change, inflammatory cells and delicate collagen fibres.

These tumors may undergo degenerative changes in the form of cyst formation, hyalinization, calcification, hemorrhage, and nuclear atypism, but, are nonetheless benign.[1] The observation of tumor acquiring such a large size within duration of 1 month is conflicting with routinely observed slow growing nature of Schwannoma. However, its inconspicuous location in the floor of the mouth and asymptomatic behavior combined with well encapsulated nature and some areas of degenerative changes in the form of hemorrhage indicate that the tumor mass is of long standing nature. S-100 is strongly expressed by most cells in Schwannoma in contrast to cells of neurofibromas, which variably expresses the antigen. Although the expression of S-100 is diminished in Antoni B areas, immunostaining for this protein is so consistent and of such intensity that it serves as an important diagnostic tool.

[5] In our patient, almost all tumor cells stained strongly for the S-100 protein, presenting as a proliferative lesion of Schwann cells. S-100 staining and the characteristic hematoxylin and eosin staining pattern confirmed the diagnosis of Schwannoma. The solitary Schwannoma is treated by surgical excision; the lesion normally will not recur. Malignant transformation is extremely rare.[2] The extensive size of this lesion, occurrence in an uncommon location and in a short period of time led to a clinical diagnosis of a malignant lesion. However, its typical histological picture of Schwannoma of both ��A�� and ��B�� type compelled us to include this large-sized tumor under the benign category as one of the diagnosis. Footnotes Source of Support: Nil Conflict of Interest: None declared.
A 28-year-old male presented to the emergency department after a road traffic accident in which he was riding a motorcycle and was hit by a truck at a speed of approximately 60 kilometres per hour. He was brought with a grossly deformed right thigh Batimastat and complained of pain in his right thigh and the inability to move it.