6% (2 CR and 11 PR) and 11 patients

had stable disease, for a disease control rate of 75%. Haematological, renal, and neurologic toxicity never exceeded grade 3 demonstrating a good tolerability of the schedule [60]. Table 3 Randomized phase II and III trials with nab-paclitaxel in melanoma. Lung cancer (LC) is the first cause of cancer death all over the world, with a 5 year survival of 5% for metastatic disease. Treatment selection is based on different factors Inhibitors,research,lifescience,medical like the performance status, comorbidities, histology, and, in the last years, the molecular mutational profile, which is now mandatory to assess before deciding treatment. The most common chemotherapy approach is a platinum based INCB018424 nmr doublet which is commonly combined with gemcitabine, vinorelbine, or pemetrexed [61] in Europe, while in the USA the most

common combination is carboplatin paclitaxel doublet (RR 15–32%); this combination is effective and relatively well tolerated in the elderly [62–65]. Bevacizumab Inhibitors,research,lifescience,medical addition to this combination led to improved survival [66]. Socinski et al. reported in 2012 a phase III trial enrolling 1052 IIIb aNSCLC (advanced non-small-cell lung cancer) patients in the first line of treatment which compared weekly nab-paclitaxel 100mg/m2 and carboplatin AUC6 every three weeks with carboplatin AUC6 and CrEL-paclitaxel 200mg/m2 every three Inhibitors,research,lifescience,medical weeks [49]. The nab-paclitaxel/carboplatin combination was more active in terms of RR with a

trend in PFS and OS improvement and was also better tolerated (Table 4). Table 4 Randomized phase III trials with nab-paclitaxel in aNSCLC. 6. Conclusions and Future Developments Nab-paclitaxel has produced a paradigm change in the treatment of tumors like breast cancer, Inhibitors,research,lifescience,medical pancreatic cancer, and melanoma and a large use in these important diseases can be predicted. Also in lung cancer, nab-paclitaxel has produced a good safety profile and increase in RR. We think that nab-paclitaxel has opened a new way to human cancer treatment and indeed reached the prime-time.
Cosmetotextiles are garments designed to contact the skin with Inhibitors,research,lifescience,medical the aim of transferring active substances useful for cosmetic purposes, particularly to combat ageing effects [1–4]. Dipeptidyl peptidase In fact, there are already several textile products on the market that claim to have certain properties that are usually found in pharmaceuticals or cosmetics [3], such as moisturising, slimming, energising, refreshing, relaxing, vitalizing, or UV-protecting properties, or are simply perfume. There is a real need to develop test methods to demonstrate and verify the effectiveness and durability of these claimed properties [5]. Encapsulation is one of the techniques used to apply such substances to textiles [6]. Liposomes are biocompatible, biodegradable, and nontoxic artificial vesicles formed by lipids that can encapsulate many compounds (hydrophilic, hydrophobic, and amphiphilic) for application to textiles.