A P value less than 0.05 was considered statistically significant. Results Compared with control group, the study group had shorter duration of invasive mechanical ventilation, non-invasive mechanical ventilation time, total mechanical ventilation time, total hospital stay (P<0.01). There are significant differences between these two groups in re-intubation rate, VAP occurred in the number of case, hospital mortality rate in 28 days (P<0.05). Three in the study group died

Inhibitors,research,lifescience,medical selleck because of exacerbation of respiratory muscle fatigue and no improvement of patients’ condition by the non-invasive mechanical ventilation. Of the three cases, two died of MODS, and one died of discontinuation treatment. Eleven in the control group died because of MODS. Of the eleven cases, five died of refusing endotracheal intubation, and two died of discontinuation treatment. 23 people in the control group were survived by using endotracheal intubation again. (Table ​(Table11) Inhibitors,research,lifescience,medical Table 1 Some medical indices in study and control groups Discussion Weaning from mechanical ventilation for COPD patients is a challenge in clinic for a long time, because of long course of diseases, recurrent cough and wheeze with infection in COPD patients, which

lead to respiratory muscle fatigue. Inhibitors,research,lifescience,medical In addition, balance of normal flora was inevitably destroyed as a result of using antibiotics long term, and influenced the body’s digestion and absorption. Patients will in high emergency condition when exacerbations, and then muscular atrophy will happen, even if it is timely to add exogenous proteins, it can’t change organization protein consumption of their own, so mal-nutrition is common in most of COPD patients. Inhibitors,research,lifescience,medical For those patients who have weaning difficulties, they will get pulmonary infection aggravated even though infection is controlled, because of respiratory muscles fatigue and weakness, sputum drained difficultly, obstructed airways repeatedly. It is well known that during long-term mechanical ventilation, due to implementation of an invasive artificial Inhibitors,research,lifescience,medical airway, ventilator associated pneumonia Electron transport chain (VAP) requiring repeated treatment often occurs. The

results show that occurring rate of VAP in the study group is obviously lower than those of the control group (P<0.01). The decrease of the incidence rate of VAP can improve the effect of treatment and decrease the medical expenditure. In a way, increasing BMI can reduce dangerous factors of VAP, strengthen the body’s immunity and decrease mortality risk. The results show that 23 people in the control group (BMI<21, but their BMI>21 by enteral nutrition combined with parenteral nutrition in treatment) were survived by using endotracheal intubation again. In this way, we know BMI is important. Pulmonary infection control window (PIC window) will appear early if the antibiotic is administrated reasonably, although the treatment of COPD is a comprehensive process.