Erlich HA: Molecular biology of rifomycin MSS Information Corp 1973. 34. Tanaka click here K, Tamaki M, Watanabe S: Effect of furanomycin on the synthesis of isoleucyl-tRNA. Biochim Biophys Acta 1969, 195:244–5.PubMed 35. Hughes J, Mellows G: Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Escherichia coli by pseudomonic acid.
Biochem J 1978, 176:305–18.PubMed 36. Kim S, Lee SW, Choi EC, Choi SY: Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics. Appl Microbiol Biotechnol 2003,61(4):278–88.PubMed 37. Dumler JS, Barbet AF, Bekker CP, Dasch GA, Palmer GH, Ray SC, Rikihisa Y, Rurangirwa FR: Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales : unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and ‘HGE agent’ as subjective synonyms of Ehrlichia
phagocytophila. Int J Syst Evol Microbiol 2001,51(Pt 6):2145–65.PubMed 38. Li L, Stoeckert CJ, Roos DS: OrthoMCL: identification of ortholog groups for eukaryotic genomes. Genome research 2003,13(9):2178–89.CrossRefPubMed 39. Raverdy S, Foster JM, Roopenian E, Carlow CKS: The Wolbachia endosymbiont of Brugia malayi has an MDV3100 solubility dmso active buy PP2 pyruvate phosphate dikinase. Mol Biochem Parasitol 2008,160(2):163–6.CrossRefPubMed 40. Hasan S, Daugelat S, Rao PSS, Schreiber M: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. PLoS Comput Biol 2006,2(6):e61.CrossRefPubMed 41. Russ AP, Lampel S: The Org 27569 druggable genome: an update. Drug Discov Today 2005,10(23–24):1607–10.CrossRefPubMed
42. Hopkins AL, Groom CR: The druggable genome. Nat Rev Drug Discov 2002,1(9):727–30.CrossRefPubMed 43. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M: DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res 2008, (36 Database):D901–6. 44. Salama NR, Shepherd B, Falkow S: Global transposon mutagenesis and essential gene analysis of Helicobacter pylori. J Bacteriol 2004,186(23):7926–35.CrossRefPubMed 45. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ: Basic local alignment search tool. J Mol Biol 1990,215(3):403–10.PubMed 46. van Dongen S: Graph clustering by flow simulation. [http://micans.org/mcl/]PhD Thesis, Univ. of Utrecht, the Netherlands 2000. 47. Edgar RC: MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res 2004,32(5):1792–7.CrossRefPubMed 48. Cormen TH, Leiserson CE, L R, Stein C: Introduction to Algorithms 2 Edition Cambridge: MIT Press 2001. Authors’ contributions AH participated in the design of the study, carried out the analyses and drafted the manuscript. PD computed minimum spanning trees and helped to draft the manuscript. JF and CC contributed to the conception of the study and helped to draft the manuscript.