For repeated

dose toxicity study, rats of either sex were orally administered with formulations at the dose of 300 mg/kg per day for a period of 28 days. The maximally tolerated dose of all formulations was found to be 2000 mg/kg. Repeated administration of formulations for 28 days did not show any significant changes in haematological and biochemical parameters in experimental animals. These results indicate that the formulations are safe, when tested in experimental animals. (c) 2015 Wiley Periodicals, Inc. and the American RG-7112 Pharmacists Association J Pharm Sci 104:1856-1863, 2015″
“A histological and morphometric study was conducted to evaluate the seasonal testicular variations in the adult Japanese quail (Coturnix coturnix japonica) in Bangladesh. The weight of birds and testes, volume, length, circumference, seminiferous tubule diameter, circumference and height of germinal epithelium of testes were measured. Sections of testes obtained from studied birds were stained with H&E and images

were taken by J software. Weight and volume of paired testes of quails significantly heavier (P smaller than 0.05) in 4EGI-1 concentration long day period of summer and rainy season (March – September) than the short day period of autumn and winter (October – February). Seasons had no significant effect on live weight gain of quails. The weight and diameter of testes or height of the germinal epithelium of the seminiferous tubule were positively correlated (r=0.84; r=0.88). Spermatogenic activity was pronounced during summer and rainy season than that of autumn and winter (P smaller than 0.05).”
“Type 2 diabetes has been associated with an increased prevalence of psychopathology, in comparison with matched non-diabetic controls. However, the cross-sectional design of most studies does

not allow causal inferences. The aim of the present study is the exploration of this possible association in patients with type 2 diabetes, in a longitudinal fashion. This prospective observational study was conducted on a consecutive series of 250 type 2 diabetic outpatients and a 1-year follow-up period was performed. At enrollment, a complete medical history was collected and hemoglobin A1c was measured. General psychopathology was assessed using the Symptom Checklist 90-revised and the Eating Disorder Examination Questionnaire. Torin 2 inhibitor Among the 187 patients available at follow-up, factors associated with unsatisfactory glycemic control at follow-up were baseline hemoglobin A1c, insulin therapy, a longer duration of diabetes, higher scores on the Eating behavior, and Somatization scales. At multivariate analysis, the attainment of hemoglobin A1c <= 7 % was associated with baseline hemoglobin A1c (p = 0.01), insulin therapy (p = 0.016), and Eating behavior (p = 0.02), whereas duration of diabetes and Somatization were no longer significant after adjusting for confounders.