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of mitotic centromere-associated kinesin overexpression in human gastric cancer. Br J Cancer 2007, 97: 543–549.CrossRefPubMed 51. Kosaka Y, Inoue H, Ohmachi T, Yokoe T, Matsumoto T, Mimori K, Tanaka F, Watanabe M, Mori M: Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Ann Surg Oncol 2007, 14: 2543–2549.CrossRefPubMed Competing interests This paper has not been published elsewhere in whole or in part. All authors have read and approved the content, and agree to submit for consideration for publication in the journal. ‘The authors declare that they have no ethical, financial or legal competing interests in this article. Authors’ contributions YL carried out nucleic acid preparation, PCR, RT-PCR and PCR-RFLP analysis, performed the statistical analysis. PL, HX and ZZ participated in tissues, information

collection and PCR- RFLP analysis. ZZ, HX and XZ participated in statistical analysis and helped to draft the manuscript. All authors read and approved the final manuscript.”
“Background Malignant tumor growth, progression, and metastasis depend on adequate blood supply [1]. Much attention has been focused on angiogenesis which is known as the sprouting GBA3 of new vessels from existing microvessels. The traditional anticancer treatment is targeting the vascular and endothelial cells [2, 3]. In 1999, Maniotis and co-workers introduced the concept of vasculogenic mimicry (VM), a new mechanism by which aggressive melanoma may acquire a blood supply [4]. VM channels are this website patterned networks of interconnected loops of periodic acid-Schiff (PAS)-positive extracellular matrix forming by aggressive melanoma tumor cells instead of endothelial cells. Moreover, it is correlated with poor prognosis in patients with tumors [4] and has been described in several other aggressive tumor types [5–8]. Uveal melanoma, the most common primary intra-ocular tumor in adults, has been widely concerned as the purely hematogenous [9]. Nearly 50% of uveal melanoma patients die from metastatic melanoma [10].

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