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BRCA genes are less well characterized, but it appears that the BRCA genes, which is effi cient human resources in the signaling cascade DNA Sch Those involved in chromatin remodeling and is involved in the activation of the pathway of Fanconi An mie. Th e discovery of BRCA BRCA and involved in HR explained Rt GDC-0941 at least partially to genomic instability T cancer and Pr Disposition that is in tears too happy to see the BRCA gene. Breast cancer accounts for about by a loss of heterozygosity at the locus in BRCA carrier hunter BRCA mutation. As a result, the tumor cells are difficult HR coefficients and are therefore potentially anf Llig for therapeutic strategies that target these sw Che.
Characteristics of homologous recombination defi cient cells is well established that cells cients challenge in HR are particularly sensitive to DNA cross-linking agents, including normal platinum-based drugs cisplatin and carboplatin, and mitomycin C, a natural anti-tumor antibiotic. Require efficient cells in BRCA, BRCA and XRCC XRCC obtained all major HR display Hte sensitivity to ICL. ICL prevent DNA sequence covalently the two beaches length of DNA to another, to st Ren replica tion and transcription. Thesis L Emissions are highly toxic to cells and not easy to repair. It appears that the combined effects of multiple pathways of DNA repair NER, TLS, and Human Resources in cooperation with the FA pathway for ICL repair, and removal of the L version Required occurs almost exclusively Lich in DNA replication.
E is the cell suggests sensitivity of the cells to define efficient RH crosslinkers that these drugs m Possibly the most eff ective in BRCA-associated tumors. Several studies have shown that patients with ovarian cancer associated with BRCA a better prognosis than their sporadic counter-parties. In a case series of patients with advanced ovarian cancer, including normal patients with BRCA gene mutations, Cass and his colleagues found that patients with BRCA mutations had a significantly better response to the significant platinum-based chemotherapy. Th authors hypothesized that this increased Hte sensitivity to cisplatin was the main reason for the improvement in overall survival. A Phase II trial in patients with breast cancer BRCA related target determine whether eff ective carboplatin chemotherapy plus s And R is more than docetaxel.
BRCA defi cient cells also showed hypersensitivity to etoposide, a topoisomerase II inhibitor. Etoposide Topoisomerase II binds to and forms a stable enzyme product DNA, thereby inhibiting ligation re fi nal step of replication is required and which leads to a DSB. Treszezamsky and colleagues showed that the two BRCA genes and BRCA defi cient cell lines of breast cancer showed sensitivity to etoposide in comparison to their counterparts BRCA completed erh Ht. Fanconi An Chemistry is a rare example FA recessive disease t x-linked, characterized by chromosomal instability, The confinement to a variety of fi ndings clinics Lich bone marrow failure, skeletal abnormalities, and other congenital anomalies, leads and early leukemia Chemistry and solid tumors. A characteristic cellular Re FA hypersensitivity to crosslinking agents, including normal mitomycin C and diepoxybutane. C In fact, quantification