In addition, high triglyceride (TG) and low high-density lipoprot

In addition, high triglyceride (TG) and low high-density lipoprotein-cholesterol (HDL-C) levels are risks factors for development of diabetes mellitus in the future.

OBJECTIVE: To examine the association between 1-h PG levels and serum lipid profiles in individuals with NGT.

METHODS: We enrolled 736 individuals with NGT who underwent a 75-g OGTT. They were divided into 2 groups, those with 1-h PG levels < 155 mg/dL (n = 543) and those with 1-h PG levels >= 155 mg/dL (n = 193). Multivariate linear regression analyses were performed to assess correlations

between 1-h PG levels and lipid profiles.

RESULTS: click here The multiple linear regression analyses showed that 1-h PG levels negatively correlated with HDL-C in individuals with NGT who had 1-h PG levels >= 155 mg/dL as well as those with 1-h PG levels < 155 mg/dL (beta = -0.137, P = .001 and beta = -0.214, P = .003, respectively). In addition, 1-h PG levels positively correlated with log-transformed TG/HDL-C ratio in both groups (beta = 0.098, P = .032 and beta = 0.152, P = .035, respectively). Moreover, even after adjusting for confounding parameters, TG was higher and HDL-C was lower in individuals with NGT who had 1-h PG levels >= 155 mg/dL compared with those who had 1-h PG levels < 155 mg/dL.

CONCLUSION: HDL-C levels and TG/HDL-C ratios closely correlate with 1-h PG levels

in individuals with NGT. Crown Copyright(C) this website Fer-1 2014 Published by Elsevier, Inc. on behalf of National Lipid Association. All rights reserved.”
“Contents Catecholamines play an important role in embryogenesis, and data obtained in the rodent model indicate that they can act even during the preimplantation period of development. Using RT-PCR with specific oligonucleotide primers distinguishing among all members of the adrenergic receptor family, we examined expression of adrenergic receptors in bovine and rabbit oocytes, morulas and blastocysts. We found several profiles of adrenoceptor mRNA expression. Transcripts for some

receptor subtypes (bovine alpha 2 receptors, rabbit 2A, 2C, 1 and 2 receptors) were detected at all examined stages, which suggests receptor expression throughout (or at most stages) the preimplantation developmental period. Expression in oocytes but not at later stages was found in only one adrenoceptor subtype (rabbit 1B). In contrast, mRNA for several adrenoceptors was found in embryos but not in oocytes (bovine beta adrenoceptors and rabbit 1A). Nucleotide sequences of our PCR products amplified in rabbit oocytes, and preimplantation embryos represent the first published mRNA sequences (partial sequences coding at least one transmembrane region) of rabbit 2C, 1 and 2 adrenoceptors. Our results suggest that the expression of adrenergic receptors can be a general feature of mammalian oocytes and preimplantation embryos.

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