In this overview, the policy perspective of the translation of ge

In this overview, the policy perspective of the translation of genomic science into selleck chemicals Health care practice is examined under the moniker of personalized medicine. The focus through this lens addresses how advances in science, technology, and health care in the United States come together while recognizing that global influences in all of these domains are increasingly relevant to the domestic picture. Currently, personalized medicine addresses two general advanced technology platforms; molecularly targeted therapeutics which are selective for a

specific biological marker (biomarker Inhibitors,research,lifescience,medical – defined as a characteristic that is objectively measured and evaluated as an indicator of

normal sellectchem biologic processes, pathogenic processes, Inhibitors,research,lifescience,medical or pharmacologic responses to a therapeutic intervention2), and molecular diagnostics. The latter, relative to the neuroscience areas, can generally be considered to include genomic diagnostic tests, biobehavioral testing measures, and imaging technologies. While recognizing Inhibitors,research,lifescience,medical the value of the contribution of many advanced imaging technologies to drug discovery and development and clinical disease state assessment, this report is principally focused on genomic diagnostic technologies. Currently, three broad medical applications of these technologies are most frequently considered as personalized Inhibitors,research,lifescience,medical medicine approaches: to determine likelihood of clinical response with molecularly targeted agents, to determine polymorphisms likely to contribute to adverse events or subtherapeutic response to drugs, and to assess disease biomarkers as predeterminants for diseases and conditions, such as heart Inhibitors,research,lifescience,medical disease, neurodegenerative disorders, and cancer. In 2006, the US Department of Health and Human Services (HHS) initiated a federal effort to coordinate and facilitate steps across the agencies to establish pathways

to enable genomic and personalized medicine to enter health care. In recognizing potential obstacles that predictive, preventive, and Brefeldin_A pre-emptive approaches to health care may face, the Personalized Health Care Initiative was launched to avoid unnecessary delays and develop effective communication strategies for the intended use of these technologies in health care. The framework for this initiative was built on two fundamental tenets: that linkage of clinical and genomic information would yield insights into human health and disease, and that the information gained from this linkage would be used, and not misused, to benefit patients and consumers.

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