It is a rare autosomal recessive condition, characterized by dry, severely thickened skin with large plates of hyperkeratotic scale, separated by deep fissures. Infants are very susceptible to metabolic abnormalities and infections. They usually do not survive for very long, but several long term survivals have been noted. The vast majority of affected individuals Quizartinib are homozygous for mutations in the ABCA12 gene, which cause a deficiency of the epidermal lipid transporter, resulting in hyperkeratosis and abnormal barrier function. We report a case of a newborn with harlequin ichthyosis,
born to unrelated parents, who had a favorable evolution with topical treatment and intensive care.”
“Purpose: To identify the main flavonoid in Adinandra nitida leaf, employ response surface methodology to optimize its ultrasonic-assisted extraction,
and determine the antioxidant activity of the obtained extract.
Methods: The main flavonoid in Adinandra nitida leaf was obtained by traditional solvent extraction and recrystallization methods, and identified by ultraviolet-visible spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), electrospray ionization-mass spectrometry (ESI-MS), nuclear magnetic resonance spectroscopy (NMR). By using response surface methodology, the effects of extraction time, ethanol concentration and ultrasonic frequency on flavonoid OICR-9429 yield were selleck chemicals investigated and optimal conditions determined. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and
reducing power of the obtained extract was also examined.
Results: The main flavonoid in Adinandra nitida leaf was identified as camellianin A. Optimal extraction conditions were as follows: extraction time, 30.25 min; ethanol concentration, 63.84 %; and ultrasonic frequency, 45 KHz. The mean experimental flavonoid yield under optimum conditions was 84.52 +/- 1.65 %, which agreed with the predicted value of 83.02 %. The obtained flavonoid extract was an effective scavenger of DPPH radicals with IC50 of 0.02 mg/mL. A linear correlation between concentration of the flavonoid extract and reducing power was observed with a coefficient of r(2) = 0.9867.
Conclusion: By using ultrasonic-assisted extraction, the main flavonoid in Adinandra nitida leaf can be obtained at a high yield. The flavonoid displays a strong DPPH radical scavenging activity and reducing power, which makes it potentially useful in the food and pharmaceuticals industries.”
“Background: Large animal models of implantable hearing devices are needed to assess innovative technologies before using them in humans. The rhesus macaque has cognitive abilities close to humans and has been used in the past but with noncommercial implants or no detailed radiologic descriptions of the surgical procedures. The aim of this study was to evaluate the feasibility of cochlear implantation in this animal model.