The differences between NOR and OFL to show the one Similar high potential to obtain 48, is due to the significant difference in energy between the excited states Ligands and their neglect of OFL.41 Ssigung of terms of Coulomb, isG is an exothermic process for all FQS Lapatinib Tykerb because E 0.930 V and 1.01 V at pH 7.50 e, however, as described above, the values for kq OFL were set below 108 million, clearly indicating that their electron-transfer reactions with amino acids are endothermic processes. This contradiction may in relation to the nature of the excited states Walls are rationalized because a FQS rehybridization occurs through a process of intramolecular charge transfer along when a FQ excited.49 Therefore must this alteration in the geometry of the cause of a decrease the capacity to accept t FQ their electronic excited states ends.
In parallel experiments showed quenching analysis of absorption spectra of w Ssrigen L Solutions of NAL and FQ in the presence of Trp and Tyr receive the new generation of transient species. In NAL, was also found that the triplet quenching by acids Tyr and Trp NAL, a method of electron transfer between the amino and 3NAL. The new intermediate by laser flash photolysis k can be observed To a radical anion and a NAL tryptophanyl or tyrosyl radicals.43 be assigned 51 In this context, carried out laser flash photolysis experiments with anaerobic L Solutions by FQ and 3 10 M Tyr or Trp showed a transient absorption spectrum of 3 s after laser pulse by overlap between the absorption spectrum of each fluoroquinolone anion radical and Trp and Tyr due.
Clear evidence of this categorization was found, then perform the same experiments under aerobic conditions, the transient absorption spectrum detected 3 s after the laser pulse corresponded to the tryptophanyl or tyrosyl radical.

The known low reactivity of t of molecular oxygen with phenoxy and indolyl anion radicals against quinolone explained Rt the results. Therefore confirm to you that the electron-transfer reactions between amino acids and 3FQs Taking into account effectively in progress. In fact, Tyr and Trp was radical formation quantum yields Born to be Similar to the corresponding spin-flip quantum yield of40 C. The reaction mixture was then ice tool Umt, a clear red L Cast made solution. This was simply with the addition of 200 ml of 5 N sodium hydroxide, which allows the separation of a yellow solid.
This was prepared by adding 200 ml of hot Em water and, after cooling, the product removed by filtration and diluted with cold water. The product was made w Recrystallized ssriger dimethylformamide to orange 1H indole-carbaldehyde 3 as small needles. 4.1.2. General Procedure for the synthesis of a 1H-indole carbaldehyde 3 A mixture of indole-3-carbaldehyde 1H, choloroacetyl chloride was, in ethanol for 10E12 h under reflux. TLC was used to monitor the progress of the reaction. After completion of the reaction, the reaction mixture to zersto Enes poured ice and filtered off with suction, the thus obtained was Pr Zipitat washed with water and recrystallized from ethanol. 4.1.3. General procedure for the synthesis of 1H-indo