“Little is known comparing and contrasting quality
of life (QoL) in patients with hepatitis C, compared to patients with other liver diseases. We performed two independent prospective cross-sectional studies including 511 and 284 patients with different forms of liver diseases. SF-36 was used in both studies. Fatigue Impact Score, WHO-BREF and Hospital Anxiety and Depression Elafibranor Scale (HADS) were used in either study only. In both studies, HCV-positive patients scored worse in the mental aspects of health-related QoL compared to other liver diseases, except for HBV in one study. Surprisingly, in both studies, quality of life was also significantly impaired in patients with viral clearance after interferon therapy but not after spontaneous clearance. Furthermore, patients with primary biliary cirrhosis showed significantly better mental health but significantly
worse physical well-being. Liver diseases differ in their form of impaired QoL. In HCV, this Rigosertib impairment might not always return to normal after treatment-induced viral clearance. This may suggest that HCV either may not be involved in QoL impairment or may induce a process which persists after viral clearance in some patients.”
“Laser-generated ultrasound in a thin composite plate with thermoviscoelastic property has been studied quantitatively. According to thermoviscoelastic theory, considering the viscoelastic and thermophysical properties of materials, a numerical model for the laser-generated Lamb waves is established in the frequency domain by using
a finite element method. It is confirmed that the temperature and displacement fields calculated in the frequency domain coincide well with those obtained in the time domain. In the numerical simulations of thermoviscoelastically generated Lamb waves, the effects of viscoelastic and elastic stiffness moduli, and the thickness of the materials have been LXH254 taken into account in details. The characteristics of the Lamb waves in the numerical results agree well with the features of the disperse curves. The results show that the finite element method in this paper provides a useful technique to characterize mechanical properties of composite materials. (c) 2010 American Institute of Physics. [doi: 10.1063/1.3520675]“
“Monitoring hepatitis C virus (HCV) infection among injecting drug users (IDUs) in the community is complicated by difficulties in obtaining biological specimens and biases in recruitment and follow-up. This study examined the utility of dried blood spot (DBS) specimens from IDUs recruited using respondent-driven sampling (RDS). Active IDUs underwent a computer-assisted interview and provided a DBS sample, tested for HCV antibody (anti-HCV) and HCV-RNA. HCV incidence was estimated from the proportion of anti-HCV-negative subjects found HCV-RNA-positive and estimates of the duration of this state.