Marbofloxacin in water dis-ences between treatment groups at baseline. The mean placement or a change in bioimpedance . The sen age of the study population was 9 years sitivity and speci ity of the clinical pitting was estimated using both water displacemen. 4 participants were women. Data from the 6 participants whopleted the and bioimpedance. March study were included in analyses.plete data . Week Week Week Assessment Bioimpedance at 0 kHz Water displacement Ankle circumference Clinical pitting Effect Size 4 CV . 8 Effect Size 1 CV . 3 Effect Size 9 CV Two subjects were excluded from the water displacement effect size at Week . Greater effect size indicates higher statistical power to detect drug-induced changes in pedal edema. measurements) or partial data from participants in the amlodipine 0-mg group were excluded from water displacement analyses due to procedural errors.

In these cas a ris which is used in shorter subjects to elevate the foot and leg to afortable height within the water ta was not used consistently throughout the study. Edema  Yohimbine Assessments Table II shows the effect sizes and CV values at each time point for the clinical assessments of pedal edema. The effect size allowed for aparison of the ability to detect drug-induced changes in edema across methodologies. It provided an indication of the magni-power. The effect size was generally larger for bioimped-ance and water displacement at each time point and in-creased with duration of drug administration. The great-est variability was observed for clinical pitti while the least variability was associated with ankle circumference measurements; the variability associated with bioimped-ance and water displacement was intermediate to clinical pitting and ankle  Agomelatine 138112-76-2 circumference.

Figure shows the mean values by time point and treatment group and changes from baseline in wa-ter displacement by time point in both treatment groups. A statistically signi ant increase from base-line in water displacement was found for amlodipine 0 mgpared with placebo at day 5 , ability; a larger effect size indicates higher statistical A B Water Displacement Mean Amlodipine 0 mg Placebo Baseline Day  . Mean and mean change  buy Erlosamide from baseline in water displacement in this study of segmental bioimpedance for measuring amlodipine-induced pedal edema. Volume 4 Number Change in Water Displacement D.A. Schoeller A Bioimpedeance at 0 kHZ Mean B Amlodipine 0 mg Placebo Amlodipine 0 mg Placebo Baseline Day 5 Day Day . Study Day Figure . Mean and mean changes from baseline bioimpedance at 0 kHz in this study of segmental bioimpedance for measuring amlodipine-induced pedal edema.

Corre-Figure shows the mean values by time point sponding standardized effect sizes for the difference between treatment groups were and . Figure shows mean values by time  anatomy point and treatment group and the change from baseline in seg-mental 0-kHz resistance by time point in both treat-and treatment group and changes from baseline in an-kle circumference by time point in both treatment groups. Statistically signi ant increases from baseline in ankle circumference were found with amlodipine 0 mgpared with placebo at day 5 , baseline in segmental bioimpedance were found with day.