(Obstet Gynecol 2011;118:824-30) DOI: 10.1097/AOG.0b013e31822f1713″
“Body weight changes in HCV patients on interferon therapy are well documented. However, the underlying mechanism involved in these changes is poorly understood and rarely reported. The PXD101 chemical structure main objectives of this review are to 1) discuss changes in body weight and other compartments

of body composition, particularly, body fat, and 2) to discuss the underlying mechanism for these changes. The literature review suggests weight loss (12-29%) as a function of interferon therapy is common, affecting up to 90% of HCV patients. Whilst, loss in weight means proportionate loss in other body compartments (lean body mass and body fat, in particular) data on changes in segmented body composition are fragmentary. The possible mechanisms underlying weight loss or changes in other body composition have been reported and these include suppressed appetite due to induction of TNF by TEN, a decrease in serum leptin level, and importantly mitochondrial damage induced by the therapy. It is, therefore, suggested that close monitoring of chronic HCV patients receiving PEG-IFN and/or ribavirin for side effects of these drugs, particularly those related to weight loss, is vitally important from clinical point of view.”
“Objectives: Nonresponse

to patient-reported outcome (PRO) questionnaires after surgery might bias the results. Our aim was to gauge the potential impact of nonresponse bias by comparing the outcomes of early and late responders.

Study Design and Setting: This study compares 59,565 early and 20,735 late responders who underwent a hip or knee replacement, selleck compound hernia repair, or varicose vein (VV) surgery. The association between timeliness of response and three outcomes (the mean

postoperative disease-specific PRO and generic PRO scores and the proportion reporting a fair or poor result) was examined by regression analysis.

Results: Late responders were slightly more likely to be young, nonwhite, deprived, and have a more severe preoperative condition with poorer quality of life. Late response was associated with a slightly poorer outcome in all four procedures although not statistically significant (P < 0.05) for VV surgery. Adjusting for Staurosporine clinical trial preoperative characteristics reduced the strength of the associations, but they remained statistically significant.

Conclusion: As nonresponse to PRO questionnaires introduces slight bias, differences in response rates between hospitals should be taken into account when making comparisons so as to avoid overestimating the performance of those with lower response rates and failing to detect poor performing hospitals. (C) 2013 Elsevier Inc. All rights reserved.”
“Background: There are several reports of lymphomas arising in the nasal cavity, either T cell/NK cell or B cell type. We studied several cases of lymphoma involving the nasal cavity or paranasal sinuses.