2%) were reported in at least two studies. Among the 61 differentially expressed miRNAs, 54 miRNAs (88.5%) were with a consistent direction, 26 were reported to be

up-gulated (Table 2) and 28 down-regulated (Table 3). The seven inconsistently reported miRNAs are listed in Table 4. Table 2 Consistently reported up-regulated miRNAs ( n  = 26) in profiling studies (lung cancer tissue check details versus normal) miRNA namea No. of studies with same direction (reference) No. of tissue samples tested Subset of studies with fold change       No. of studies No. of tissue samples tested Mean fold change Range miR-210 9 (19,22,24,25,26,27,29,30,32) STI571 manufacturer 796 6 449 2.65 1.51 – 5.10 miR-21 7 (19,21,25,28,29,30,32) 448 6 240 4.39 1.74 – 13.60 miR-182 6 (22,24,26,27,28,32) 496 4 357 6.34 1.85 – 19.00 miR-31 6 (21,22,26,27,29,32) 425 5 357 2.89 1.58 – 4.80 miR-205 5 (26,27,28,29,30) 417 3 141 23.20 2.99 – 54.30 miR-200b 5 (19,25,26,28,32) 262 4 194 3.69 1.30 – 9.80 miR-183 4 (22,24,27,28) 388 3 317 5.94 2.11 – 11.60 miR-203 3 (24,26,30) 347 0 – CDK inhibitor – - miR-196a 3 (22,27,28) 317 3 317 37.50 2.10 – 101.80 miR-708 3 (22,27,29) 301 3 301 3.20 1.85 – 5.50 miR-92b 3 (27,28,32) 151 3 151 3.71 1.54 – 6.80 miR-193b 3 (21,26,27) 149 2 81 4.68 2.56 – 6.80 miR-106a 2 (24,30) 279 0 – - – miR-21* 2 (22,27) 271 2 271

2.23 2.16 – 2.30 miR-135b 2 (21,22) 222 2 222 2.29 2.28 – 2.31 miR-96 2 (22,23) 218 2 218 171.56 2.30 – 340.81 miR-17-5p 2 (24,27) 136 1 65 3.80 – miR-20b 2 (24,28) 117 1 46 5.70 – miR-18a 2 (26,28)

114 1 46 7.80 – miR-200a 2 (24,32) 111 1 40 1.86 – miR-93 2 (24,32) 111 1 40 1.68 – miR-130b 2 (26,32) 108 1 40 1.57 – miR-200c 2 (24,29) 101 1 30 1.66 – miR-375 2 (28,32) 86 2 86 5.35 2.89 – 7.80 miR-20a 2 (20,24) 83 0 – - – miR-18b 2 (20,26) 80 0 – - – a The asterisk is part of the miRNA nomenclature system and is not linked to any footnote specific to this table. Table 3 Consistently Anidulafungin (LY303366) reported down-regulated miRNAs ( n  = 28) in profiling studies (lung cancer tissue versus normal) miRNA namea No. of studies with same direction (reference) Total number of tissue samples tested Subset of studies with fold change       No. of studies Total number of tissue samples tested Mean fold change Range miR-126 10 (19,21,25,26,27, 28,29,30,31,32) 587 8 311 0.33 0.00 – 0.69 miR-30a 8 (19,21,25,26,27,28,29,31) 339 7 271 0.36 0.04 – 0.61 miR-451 6 (19,21,25,27,28,29) 265 6 265 0.37 0.01 – 0.53 miR-486-5p 5 (19,22,26,27,28) 437 4 369 0.39 0.13 – 0.53 miR-30d 5 (21,25,28,29,31) 154 5 154 0.34 0.08 – 0.57 miR-145 4 (26,28,30,32) 362 2 86 0.23 0.09 – 0.38 miR-143 4 (21,28,30,32) 310 3 102 0.33 0.13 – 0.59 miR-139-5p 3 (22,27,29) 301 3 301 0.55 0.40 – 0.64 miR-126* 3 (21,25,30) 280 2 72 0.33 0.20 – 0.45 miR-140-3p 3 (26,27,28) 179 2 111 0.29 0.17 – 0.42 miR-138 3 (25,26,32) 164 2 96 0.64 0.56 – 0.72 miR-30b 3 (25,28,29) 132 3 132 0.41 0.11 – 0.