Oncogene 2010, 29:4576–4587.PubMed 176. Harney A, Meade T, LaBonne C: Targeted inactivation of snail family EMT regulatory factors by a Co(III)-Ebox conjugate. PLoS One 2012, 7:e32318.PubMedCentralPubMed 177. Javaid S, Zhang J, Anderssen buy Trichostatin A E, Black JC, Wittner BS, Tajima K, Ting DT, Smolen GA, Zubrowski M, Desai R, Maheswaran S, Ramaswamy S, Whetstine JR, Haber DA: Dynamic chromatin modification sustains epithelial-mesenchymal
transition following inducible expression of Snail-1. Cell Rep 2013, 5:1679–1689.PubMedCentralPubMed 178. Shah P, Gau Y, Sabnis G: Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin. Breast Cancer Res Treat 2014, 143:99–111.PubMed 179. Hatzivassiliou G, Haling JF, Chen H, Song K, Price S, Heald R, Hewitt JF, Zak M, Peck A, Orr C, Merchant M, Hoeflich KP, Chan J, Luoh SM, Anderson DJ, Ludlam MJ, Wiesmann C, Ultsch M, Friedman LS, Malek S, Belvin M: Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature 2013, 501:232–236.PubMed 180. Miller C, Oliver K, Farley J: MEK1/2 inhibitors in the treatment
of gynecologic find more malignancies. Gynecol Oncol 2014, 133:128–137.PubMed 181. McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Franklin RA, Montalto G, Cervello M, Libra M, Candido S, Malaponte G, Mazzarino MC, Selleck LCZ696 Fagone P, Nicoletti F, Bäsecke J, Mijatovic S, Maksimovic-Ivanic D, Milella M, Tafuri A, Chiarini F, Evangelisti C, Cocco L, Martelli AM: Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget 2012, 3:1068–1111.PubMedCentralPubMed
182. NIH Database.. next http://clinicaltrials.gov. 183. Mimasu S, Sengoku T, Fukuzawa S, Umehara T, Yokoyama S: Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25 Å. Biochem Biophys Res Commun 2008, 366:15–22.PubMed 184. Pubchem Database.. [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=444732&loc=ec_rcs] 185. Pubchem Database.. [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4688&loc=ec_rcs] 186. Pubchem Database.. [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6918837] 187. Pubchem Database.. [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4261] Competing interests The authors declare that they have no competing interests. Authors’ contributions SK was responsible for reviewing the literature, summarizing data and preparing a draft of the manuscript. BB conceptualized and developed an outline for the manuscript as well as edited the manuscript for publication. Both authors read and approved the final manuscript.