Patients who required ICU admission were LY411575 ic50 at increased risk for early death following discharge compared with those who died after a period ≥3 months (14/ 17 [82.4%] vs. 48/102 patients [47.1%], respectively, p < 0.01). Early versus late death was also associated with transfusion of blood products (12 /17 patients [70.6%] vs. 43/102 patients [42.2%], respectively,

p = 0.04) and with the development of in-hospital complications (7/17 [41.2%] vs. 16/102 [15.7%], respectively, p = 0.02). ISS was noted to be higher for those who died early, but this difference did not reach statistical significance (mean ISS 25.1 ± 10.7, vs. 21.3 ± 6.9, respectively, p = 0.05). The pattern of injury, GCS upon arrival, and co-morbidities were not different between the groups. Table 4 Univariate analysis of early versus late mortality   Early death (<3 months) Late death ( ≥3 months) P value   (n = 17) (n = 102)   Age (mean ± SD) 81.1 ± 6.8 79.9 ± 10.0 NS Males (n, %) 9 (52.9)

57 (55.9) NS MOI (n, %)   Fall 14 (82.4) 79 (77.5) NS   MVA car 1 (5.9) 7(6.9) NS   MVA pedestrian 2 (11.8) 8 (7.8) NS   Other 0 (0) 8 (7.8) NS ISS (Median, range) 25 (16-25) 17 (16-25) 0.1 Probability of survival (mean ± SD) 69.9 ± 28.9 79.4 ± 23.6 0.1 Head trauma (n, %) 12 (70.6) 65 (63.7) NS GCS upon admission (mean ± SD) 10.9 ± 4.6 12 ± 4.1 NS Intubation (n, %)   At scene 2 (11.8) 9 (8.8) NS   In ED 1 (5.9) 7 (6.9) NS Required operation (n, %) 8(47.1) 30 (29.4) NS LOS (mean ± SD) LDN-193189 28.8 ± 19.4 18.6 ± 19.2 <0.05 Admitted to ICU (n, %) 14 (82.4) 48 (47.1) <0.01 Blood transfusion (n, %) 12 (70.6) 43 (42.2) 0.04 In-hospital complications (n, %) 7 (41.2) 16 (15.7) 0.02 Discharge destination (n, %)   Rehabilitation 2 (11.8) 16 (15.7) NS   Home 1 (5.9) 34 (33.3) 0.02   Assistant living facility 14 (82.4) 51 (50.0) 0.02   Other hospital 0 (0.0) 1 (1.0) NS NS–not significant; MOI–mechanism of injury; MVA–motor Tideglusib vehicle

accidents; ED–Emergency Department; ICU–intensive care unit. Data shown as number (and percentage) and mean (±SD). Predictors of long-term survival Univariate survival curves demonstrated that age, mechanism of injury, GCS upon admission and discharge destination were significantly associated with long-term survival (Figure 1). Multivariate analysis was performed to analyze those factors predictive of survival. Parameters which were found to be significant on univariate analysis were entered into a forward stepwise Cox regression model. As noted age, fall as mechanism of injury, GCS and renal failure upon admission and discharge destination were found to be predictors of long term survival (Table 5). Figure 1 Cox regression model for parameters predicting early post discharge death: age >80; fall as a mechanism of injury; discharge to assisted living facility (ALF); low GCS on arrival to emergency ISRIB chemical structure Department. Table 5 Predictors of long term survival in severely injured elderly trauma patients   Adjusted hazard ratio 95% confidence interval P value Age 1.044 1.022-1.065 <0.