She previously served as chair of the Anthropology Department at the University
of Colorado Denver and Dean of the Graduate School of Arts & Sciences at Wake Forest University. “
“Please cite this paper as: Shankar, Sabanayagam, Klein and Klein (2011). Retinal Microvascular Changes and the Risk of Developing Obesity: Population-based Cohort Study. Microcirculation18(8), 655–662. Background: Recent studies have hypothesized that endothelial and microvascular dysfunction may play a role in the development of obesity. Previous studies have shown that retinal microvascular changes are associated with diabetes, hypertension, and cardiovascular disease. In contrast, few prospective studies have examined the association between retinal microvascular changes and the risk of developing obesity. RO4929097 Methods:
We examined n = 2089 nonobese subjects from a population-based cohort in Beaver Dam, Wisconsin (aged 44–85 years, 49% women). Retinal arteriolar and venular diameters were measured from baseline retinal photographs. The main outcome-of-interest was 15-year incidence of obesity. Results: Retinal venular LEE011 supplier widening was positively associated with incident obesity over a 15-year follow-up period. This association was independent of age, gender, smoking, alcohol intake, education, physical activity, body mass index, serum cholesterol,
and C-reactive protein levels. Compared with subjects with retinal venular diameter in the lowest tertile (referent), the multivariable relative risk (95% confidence interval) of obesity among subjects in the highest tertile was 1.68 (1.24–2.28); p-trend = 0.0005. In contrast, narrow retinal arterioles were not associated Ergoloid with obesity. Conclusions: In a population-based cohort, we found that wider retinal venules are positively associated with risk of developing obesity, suggesting a role for microvascular dysfunction in its etiology. “
“The EG regulates vascular homeostasis and has anti-atherogenic properties. SDF imaging allows for noninvasive visualization of microvessels and automated estimation of EG dimensions. We aimed to assess whether microcirculatory EG dimension is related to cardiovascular disease. Sublingual EG dimension was estimated by SDF imaging in healthy volunteers and in patients visiting an outpatient clinic for vascular medicine of a university hospital in Amsterdam, the Netherlands. EG dimension was compared among healthy volunteers, patients with CVD, and patients at low (<10%) or high risk (≥10%) of CVD according to the Framingham algorithm. In total 120 patients and 30 healthy volunteers were included. Patients had a mean age of 59 ± 14 years, 71 (59%) were men and 24 (20%) were black.