The adjusted means and standard errors for the untransformed Obeticholic Acid molecular weight FECs are presented, with statistical inferences based upon the transformed data.

An analysis of variance (ANOVA) was carried out on the log10 worm count data and the data for the levels of copper in the organs at slaughter, examining the effects of COWP treatment on these variables. The ANOVA was also applied to the FEC and PCV data to determine whether the values differed for specific days. The effects of castration and day −2 values were examined but found not to be significant. Fisher’s protected least significant difference test was used to separate the means at the 1% level. As with the FECs, the untransformed values are reported in the text and tables. The percentages reduction in worm count in the treated groups relative to the controls were calculated according to the formula, ((C − T)/C) × 100, where C and T are the untransformed, arithmetic means of the untreated and treated groups, respectively. Mean liver copper levels tended MG132 to be higher in the treated goats than in the controls removed from pasture 7 days post treatment and slaughtered 28 days later (P = 0.022; Table 2), but did not differ in the goats removed from pasture 28 or 56 days after treatment and slaughtered 28 days later. There were no significant differences in the copper levels in the kidney, muscle and faecal samples at

slaughter (P ≥ 0.09). The climatic data for the period of the study are presented in Fig. 1. Temperatures declined during the experimental period, as did rainfall. There was a consequent need for artificial irrigation of the pasture. The effect of castration was not significant for FEC, PCV or body condition score and it was only included as a factor in the analysis for live weight. While the effect of castration was significant for all three sets of goats, the differences were minor (0.35–0.6 kg), were inconsistently different between the groups

and were of oxyclozanide no practical significance. The goats grew over the course of the experiment (day, P < 0.001 for all three sets of goats; Fig. 2), but for reasons that are unknown, the 7 d goats decreased in weight in the week preceding slaughter (on days 34 and 36). The treatment main effect was significant for the groups removed at 28 days and 56 days post treatment (P < 0.001) but again these differences were of little biological importance. The interactions of day × treatment and day × castration were not significant for any of the three sets of goats (P ≥ 0.028). The treatment main effect on body condition score was not significant for any of the three sets of goats (P > 0.13) and the day main effect was only significant for the goats removed from pasture at 56 days (P = 0.002). The latter group increased in body condition score from 3.1 ± 0.1 at the start of the experiment (day −2) to 3.5 ± 0.1 at the end (day 82), whereas the goats removed from pasture at day 7 remained around 3.