“The authors would like to make an addition to the acknowl


“The authors would like to make an addition to the acknowledgments section and acknowledge the financial support of Action Medical Research, UK.


“The authors would like to make an addition to the acknowledgments section and acknowledge the financial support of Action Medical Research PI3K Inhibitor Library clinical trial (SP4506). “
“In 2002, the National Cancer Institute (NCI), in collaboration with other Institutes and Centers of the National Institutes of Health, convened a meeting of scientific experts to discuss seminal research on behavioral, neural, endocrine, and immune system interactions in health and disease. To inform the development of a biobehavioral research agenda in cancer control, knowledge was extracted from contemporary studies of neuroimmune mechanisms of subjective experiences (e.g., stress, loneliness, and pain), biological processes (e.g., circadian rhythmicity, sleep, wound healing, sickness

behavior, and apoptosis), and disease outcomes (e.g., human immunodeficiency virus, depression, and post-traumatic stress disorder). Brain, Behavior, and Immunity published the Biological Mechanisms of Psychosocial Effects on Disease supplement in February 2003. This seminal volume captured state-of-the-science reviews and commentaries by leading experts in psychoneuroimmunology (PNI) and served as a catalyst for biobehavioral 1 research www.selleckchem.com/screening/selective-library.html conducted in a cancer context. In the decade prior to the NCI commissioned supplement, Brain, Behavior, and Immunity published only 12 cancer-relevant articles. Since the 2003 supplement, the journal has featured 128 cancer-relevant papers that have generated 3361 citations (data from SCOPUS, retrieved November 1, 2012), relative to 55 papers on PNI and cancer, published in other peer review journals during the same time period. Dolichyl-phosphate-mannose-protein mannosyltransferase These bibliometric data highlight Brain, Behavior, and Immunity as a leading scholarly outlet for research on the biology of psychological and social experiences and the integrated mechanisms associated with cancer as a complex disease process. The current volume celebrates

the 10-year anniversary of the 2003 supplement. This collection of invited reviews and research articles captures important discoveries, paradigm shifts, and methodological innovations that have emerged in the past decade to advance mechanistic and translational understanding of biobehavioral influences on tumor biology, cancer treatment-related sequelae, and cancer outcomes. Early clinical investigations focused almost exclusively on psychosocial modulations of the humoral and cellular immune response and, to some extent, on DNA repair (Andersen et al., 1994, Antoni, 2003, Kiecolt-Glaser and Glaser, 1999 and Kiecolt-Glaser et al., 2002). Women at an increased genetic risk for cancer exhibited specific immune impairments and abnormalities in their endocrine response to stress (Bovbjerg and Valdimarsdottir, 1993, Dettenborn et al., 2005 and Gold et al., 2003).

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