The authors would like to thank Dr Gary Sibbett (The Beatson Inst

The authors would like to thank Dr Gary Sibbett (The Beatson Institute for Cancer Research, Glasgow, UK) for having kindly provided the plasmids for retrovirus production, Dr Gabriella click here Zupi (Regina Elena Cancer Institute) for having kindly supplied the M14 and FRM cell lines, Dr. Daniela Di Sciullo,

Mr. Vincenzo Peresempio for their skilled technical assistance. Dr Irene Terrenato for her help with statistical work and Dr Marco Ravaioli for linguistic revision of the manuscript. References 1. zur Hausen H: Papillomavirus infections–a major cause of human cancers. Biochim Biophys Acta 1996, 1288: F55–78.PubMed 2. zur Hausen H: Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002, 2: 342–50.CrossRefPubMed 3. Munger K, Phelps WC, Bubb V, Howley PM, Schlegel R:

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J Virol 1989, 63: 4417–21.PubMed 4. Thomas M, Pim D, Banks L: The Role of HPV E6 Oncoprotein in Malignant buy MK-2206 Progression. In Papillomavirus Research – From natural history to Vaccines and Beyond. Edited by: Campo MS. Norfolk: Caister Academic Press; 2006:115–132. 5. McCance DJ: The Biology of the E7 Protein of HPV16. In Papillomavirus Research – From natural history to Vaccines and Beyond. Edited by: Campo MS. Norfolk: Caister Academic Press; 2006:133–144. 6. Leptak C, Ramon y Cajal S, Kulke R, Horwitz BH, Riese DJ 2nd, Dotto GP, DiMaio D: Tumorigenic transformation

of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16. J Virol 1991, 65: 7078–83.PubMed 7. Bouvard V, Matlashewski G, Gu ZM, Storey A, Banks L: The human papillomavirus Carnitine dehydrogenase type 16 E5 gene cooperates with the E7 gene to stimulate proliferation of primary cells and increases viral gene expression. Virology 1994, 203: 73–80.CrossRefPubMed 8. Valle GF, Banks L: The human papillomavirus (HPV)-6 and HPV-16 E5 proteins co-operate with HPV-16 E7 in the transformation of primary rodent cells. J Gen Virol 1995, 76: 1239–45.CrossRefPubMed 9. Bravo IG, Alonso A: Mucosal Human Papillomaviruses Encode Four Different E5 Proteins Whose Chemistry and Phylogeny Correlate with Malignant or Benign Growth. J Virology 2004, 78: 13613–13626.CrossRefPubMed 10. Schiffman M, Herrero R, Desalle R, Hildesheim A, Wacholder S, Rodriguez AC, Bratti MC, Sherman ME, Morales J, Guillen D, Alfaro M, Hutchinson M, Wright TC, Solomon D, Chen Z, Schussler J, Castle PE, Burk RD: The Selleck Doramapimod carcinogenicity of human papillomavirus types reflects viral evolution. Virology 2005, 337: 76–84.CrossRefPubMed 11. Conrad M, Bubb VJ, Schlegel R: The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein. J Virol 1993, 67: 6170–8.PubMed 12.

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