There were 2492 incident cases of ischemic stroke occurring in 1995 click here 2007 giving a crude annual Inhibitors,Modulators,Libraries incidence of 72 per 100,000 population. There were on average 2. 63 ischemic stroke cases observed per census output area. With regard to observed counts for subtypes and severity, this average ranged from 0. 14 for large artery atherosclerosis to 1. 36 for mild stroke defined using the clinical severity classification. We mapped the stroke data and no unusual patterns or clustering were observed. Of the 2492 ischemic strokes, 473 had TACI, 762 had PACI, 362 had POCI, 860 had LACI and the remaining 35 had no sub classification assigned. Table 1 shows that patients with TACI had severe stroke on both NIHSS and clinical severity classifications. Patients with LACI tended to have less severe stroke.

There were 136 stroke cases classified as attributable to large artery atherosclerosis, 371 classified as attributable to cardioembolism and 376 classified as attributable to small vessel occlusion from 2000 2007. Patients with ischemic stroke caused by large artery atherosclerosis had more Inhibitors,Modulators,Libraries severe stroke. Similarly, patients with ischemic stroke caused by cardioembolism had more severe stroke. In contrast, patients classified as having ischemic stroke caused by small vessel Inhibitors,Modulators,Libraries occlusion had less severe stroke, with 26. 9% and 24. 2% classified as having severe stroke based on NIHSS and clinical severity respectively. With regard to severity, 1051 patients with ischemic stroke were classified by severity based on the NIHSS score.

All ischemic strokes could be classified by clinical severity, Inhibitors,Modulators,Libraries with 1207 classified as severe and 1285 classified as mild. Patients Inhibitors,Modulators,Libraries with severe stroke were older, with a lower proportion of males. There was moderate concordance between clinical severity and NIHSS severity, assessed in the 1051 patients with severity classified using both measures. Table 2 gives rate ratios associated with increases in PM10 concentration. There were no significant associations between PM10 and any of the Oxford or TOAST subtypes or with NIHSS severity categories. There was, however, a significant association with mild stroke based on the clinical severity classification, when PM10 concentration was examined as a categorical variable by tertile. The rate ratio in the highest category of PM10 was 1. 20 relative to the lowest category.

Table 3 gives rate ratios associated with increases directly in NO2 concentration and the overall picture was very similar to that for PM10. There were no significant associations with any of the Oxford or TOAST subtypes or with either of the NIHSS severity categories. However, there was a significant association between NO2 concentration examined using tertiles and mild stroke. The rate ratio in the highest NO2 category was 1. 22 compared with the lowest NO2 category.