Icity was 900 mg / kg day, the Wee1-like protein kinase hour HIGHEST dose tested. The Committee also considered the Entwicklungstoxizit t of metolachlor ESA and found that both maternal and development NOAEL for this degradation product of more than 1000 mg / kg day are the hours HIGHEST dose tested, suggesting that Entwicklungstoxizit t is not a problem for these acetanilide degradation products. For acetochlor OXA, female Sprague-Dawley rats were again U-test material in distilled water by gavage at a dose of 0, 250, 500 or 1000 mg / kg per day once t Possible for GDS 6 to 19 and were sacrificed on GD 20. There was the potential for maternal toxicity T as the maternal mortality in two of 25 Staud Strains in a dose of 1000 mg / kg per day demonstrated. The autopsy findings revealed no test article internal dose at any time. There were no effects on fetal growth and survival of pups evaluated for each dose. Were some anomalies and changes Entwicklungsst At F, As observed in this study, but as a spontaneous origin, and not to test in connection with the administration section. The Panel concluded that the NOAEL for maternal toxicity t was 500 mg / kg of t Possible, may need during the NOAEL for Entwicklungstoxizit t was 1000 mg / kg per day. The group also concluded that there is no impact on the development testing at the h Chsten doses for alachlor ESA and acetochlor OXA, and h Chsten doses tested in erismodegib NVP-LDE225 these two studies are toxicity t NOAEL development. Since the available data in two ways, rats and rabbits that chemicals Mothers developmental effects only for the mother or h Ago toxic amounts leads, the Panel also considered whether the development of studies were available for the two metabolites sufficient toxicity to t to evaluate the development of the four degradation products and to address the lack of results from tests with a second species. The Committee agreed provided that the available data in order for the two degradation products of limited concern Entwicklungstoxizit t for one of the degradation products. This decision was affecting the overall similarity, structurally Toxicity similar t of degradation products and uniformly Ig low gastrointestinal absorption. Since it is au Addition Entwicklungstoxizit t of negative criticism for chemicals toxic parents, and the final assessment of the U.S. Umweltbeh Rde EPA is concluded that the quality of t of food Protection Act deems a factor to be sufficient for the parents who completed the Committee that there is only limited concern for Entwicklungstoxizit t of degradation products, but he r a umte that the lack of data for the untested degradation products still represent a gap of data. 3.1.5. Other m Possible impacts on critical studies identified several clinical signs of toxicity t with m Matched negative critical collaboration. As part of the reference potential doses were considered as significant clinical signs of alachlor ESA, the results of the study of drinking water. In the study of drinking water, clinical signs were at the h Observed higher Bergenin dose of 20,000 ppm. This result was confirmed by observation of clinical signs at a feed concentration of 20,000 ppm in the 28-t Best pendent study CONFIRMS, but not in a feeding study a 90-t Dependent dietary concentrations up to 12,000 ppm. The discrepancies between the di t for 90 days and 91 days study of drinking water for alachlor ESA was established in order to determine whether clinical symptoms could be attributed examined.