Safety: The efficacy and safety Zoledronate 118072-93-8 of prasugrel compared with those of clopidogrel in the study on the improvement of therapeutic results by optimizing platelet inhibition with prasugrel thrombolysis in myocardial infarction 38 assessment. In this trial 214 patients undergoing a PCI 13.608 ACS-covered, prasugrel to clopidogrel was compared with standard dose. Compared with clopidogrel, prasugrel reduced the prime Ren composite endpoint of heart attack, stroke or kardiovaskul Things, death and stent thrombosis, but does not reduce overall mortality and a significant increase in life-threatening, and t Dlichen bleeding. Secondary Ranalysen suggested that the gr Th Nutznie He ts of prasugrel occurred in patients with ST-segment elevation MI, is a framework for quickly and completely Requests reference requests getting the inhibition Blutpl Ttchen crucial, and documented in diabetics, a population of patients to have uniformly on ig high Thrombozytenreaktivit t, despite treatment with aspirin and clopidogrel therapy. The excess bleeding with prasugrel refl ects its faster onset of action, his gr-Run performance, and m is for may have his most consistent effects of platelet aggregation inhibitors. The FDA approval of prasugrel came with a warning regarding the risk of significant tilting or t Dliche bleeding. The drug-cons is indicated in patients with active bleeding or a stroke. Antiplatelet manage targeted for improved laser optimal strategy for acute medical reasons too small Coronary syndrome study is to assess whether a beneficiary favorable t / risk by reducing the dose can be achieved by prasugrel. Cilostazol 3.4 dihydro-quinolinone 2] obtained Intracellular ht Re levels of cyclic AMP by inhibiting phosphodiesterase type III. In a rat model in which ligation of both common carotid artery used for vascular Was to simulate re dementia, cilostazol showed protective effects against hypoperfusion-induced cognitive adversely caning and white S substance. The importance of the cAMP response element high-protein phosphorylation by cilostazol was liaison with high CK2 and Akt phosphorylation and increased stressed Hte Bcl-2 levels with reduced caspase 3 activity t in the region of penumbra of focal isch Mix rat brain. Cognitive dysfunction in rats, chronic cerebral hypoperfusion which became also improved thanks to an efficient up-regulation of the phosphorylation of CREB by coadministration of cilostazol with donepezil. A recent study in human patients with AD reported that the combination therapy of donepezil with cilostazol significantly improved the Mini Mental State Examination score and the condition not Maintained until changed by the end of follow-up period. More recently, our employees have shown that cilostazol chtnisst Ged Changes significantly improved by intrazerebroventrikul Re injection of AB25 35 C57BL/6J-M Mice induced, and found that the phosphorylation of tau in N2a cells expressing human cilostazol reduced fa is stable, mutation buy parthenolide of the Preferences shore amylo-protein of Sweden. CK2 contr The function of many proteins By phosphorylation. Previously, we reported that cilostazol CK2 activated in the cells SK N SH, inactivation of the phosphatase and tensin homolog on chromosome 10 and the improvement of the Akt / CREB phosphorylation gel Deleted, thus erh Increase anti-apoptotic effects, these results were in brain tissue best CONFIRMS.