Bioinformatics 2007, 23:1556–1558 PubMedCrossRef 56 Kimura M: A

Bioinformatics 2007, 23:1556–1558.PubMedCrossRef 56. Kimura M: A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol 1980,16(2):111–120.PubMedCrossRef 57. Pride D: SWAAP Version 1.0 -Sliding windows alignment analysis program: a tool for analyzing patterns of substitutions and similarity in multiple alignments.

Distributed by the author 2000. 58. Ogata H, Goto S, Sato K, Fujibuchi W, Bono H, Kanehisa M: KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res 1999,27(1):29–34.PubMedCrossRef 59. Wu CH, Huang H, Arminski L, Castro-Alvear J, Chen Y, Hu ZZ, Ledley RS, Lewis KC, Mewes HW, Orcutt BC, et al.: The Protein Information Resource: an integrated public resource of functional annotation of proteins. Nucleic acids research 2002,30(1):35–37.PubMedCrossRef 60. Katoh K, Toh H: BVD-523 molecular weight Recent developments in the MAFFT multiple sequence Crenigacestat clinical trial alignment

program. Brief Bioinform 2008,9(4):286–298.PubMedCrossRef 61. Waterhouse A, Procter J, Martin D, Clamp M, Barton G: Jalview Version 2 – a multiple sequence alignment editor and analysis workbench. Bioinformatics 2009,25(9):1189–1191.PubMedCrossRef 62. Castresana J: Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. Mol Biol Evol 2000, 17:540–552.PubMedCrossRef 63. Nei M, Gojobori T: Simple methods for estimating the GSK2879552 order numbers of synonymous and nonsynonymous nucleotide substitutions. Mol Biol Evol 1986,3(5):418–426.PubMed 64. Ziheng Y: PAML 4: Phylogenetic Analysis by Maximum Likelihood. Mol Biol Evol 2007,24(8):1586–1591.CrossRef 65. Yang Z, Nielsen R, Goldman N, Pedersen A: Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics 2000,155(1):431–449.PubMed 66. Fares M, Byrne K, Wolfe K: Rate asymmetry Beta adrenergic receptor kinase after genome duplication causes substantial long-branch attraction artifacts in the phylogeny of Saccharomyces species. Mol Biol Evol 2006,23(2):245–253.PubMedCrossRef 67. Yang Z, Wong WNR: Bayes empirical Bayes inference of amino acid sites under positive selection. Mol Biol Evol 2005, 22:1107–1118.PubMedCrossRef

Competing interests The authors declare no competing interests. Authors’ contributions HSV planned the study design and performed all the bioinformatic analyses. YY made the Korean isolates available for this study and provided insightful comments with regard to outer membrane proteins of H. pylori. TT sequenced pldA, genotyped CagA from the Norwegian and Korean isolates and contributed throughout the process. GB supervised the study. All authors read and approved the final manuscript.”
“Background Interstitial Cystitis or Painful Bladder Syndrome (IC/PBS) is a chronic condition characterized by frequent urination and bladder pain, which often results in reduced quality of life. Clinicians experience that this disease is becoming more prevalent [1].

Comments are closed.