Magnetic resonance imaging (MRI) revealed right thrombophlebitis extending from the sigmoid sinus to the jugular vein.
Interventions: Systemic administration of adrenocortical steroid hormone after intravenous antibiotic therapy.
Main Outcome Measures: Radiologic features and patient symptoms.
Results: Intravenous antibiotic therapy was ineffective, but selleck products the patient’s symptoms were relieved less than 1 day after the initiation of prednisolone treatment (30 mg/d for 5 d). MRI performed 3 days after treatment revealed that thrombophlebitis of the head and neck had disappeared.
Conclusion: Adrenocortical steroid hormone therapy may be an effective
treatment for thrombophlebitis with EOM. Chemoattractants activated by EOM might be
associated with the pathogenesis of thrombophlebitis of the head and neck.”
“Purpose: To evaluate the effect of a w/o cream of turmeric (Curcuma longa Zingiberaceae) extract on skin sebum secretion in human volunteers.
Methods: Two w/o cream formulations were prepared – one contained 5% extract prepared from the rhizomes of the plant, turmeric, and the second was similar except that it did not contain the extract and served as control. The antioxidant activity of the extract was determined by using the DPPH method. Evaluation of the effect of the creams Liproxstatin 1 on skin sebum secretion was conducted with the aid of a sebumeter. Initial sebum measurements on the face of thirteen human volunteers were taken with the sebumeter prior to application of cream, and then fortnightly after twice daily application of cream (on the right and left cheeks for control and extract creams, respectively) over a period of three months.
Results: Significant increase (p < 0.05) in the sebum values was observed from the 6th week onwards after control cream application. Maximum increase of 6.2% was observed on the 10th
week of the study. On the other hand, following extract cream application, a significant decrease (p < 0.05) in sebum secretion occurred from the 4th week onwards, reaching a maximum of 24.8% at the end of the study period. The antioxidant activity of the extract was 88.5% of selleck inhibitor the standard.
Conclusion: The study demonstrates that the extract obtained from the rhizomes of turmeric plant can be used in skin preparations to regulate excessive sebum secretion in persons suffering from acne and related problems.”
“Objective. To characterize the pharmacokinetics of nifedipine when used for tocolysis in preterm labor and to determine the impact of genetics on these parameters.
Study design. Pharmacokinetic study performed on women given tocolytic nifedipine. Over one dosing interval, drug concentrations, clinical data, and genotype for Cytochrome P450 (CYP)3A5 polymorphisms were obtained. Non-compartmental pharmacokinetic analysis was used to estimate nifedipine exposure at steady state.
Results. The mean nifedipine area under the curve in 20 pregnant women was 86.1 +/- 61.1 ng/ml/h.