“
“Objective.

To investigate KPT-8602 in vitro the characteristics of mismatch negativity (MMN) in chronic pain patients and the effect of chronic pain on MMN morphology in order to supply the neurophysiological evidence on preattentive processing abnormalities in chronic pain patients.

Study Design.

We evaluated the auditory MMN to frequency deviance in patients with chronic pain and healthy controls. Emotion was assessed using the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI), and pain intensity was assessed using the short-form McGill

Pain Questionnaire (SF-MPQ).

Subjects and Settings.

Subjects included 20 outpatients with chronic pain lasting for at least 6 months and 20 healthy controls.

Results.

MMN latencies in chronic pain patients were significantly delayed relative to healthy controls (P < 0.001). MMN latency was positively correlated with duration of chronic pain and negatively correlated with the SF-MPQ affective index. MMN amplitudes were similar between chronic pain patients and controls, and MMN morphology did not correlate with age, education level, BDI, BAI, visual analog scale, or the SF-MPQ sensory index.

Conclusions.

The preattentive processing speed in chronic pain patients is decreased; the longer a

person experiences chronic pain and the more severe the affective component of pain are, the more likely they are to demonstrate preattentive processing difficulties.”
“Background and objective: Whether the therapeutic nasal continuous positive airway pressure (CPAP) derived from manual titration is the same as derived from automatic titration is controversial. The purpose of this study NVP-BSK805 was to compare the therapeutic pressure derived from manual titration with automatic titration.

Methods: Fifty-one patients with obstructive sleep apnoea (OSA) (mean apnoea/hypopnoea index (AHI) = 50.6 +/- 18.6 learn more events/h) who were newly diagnosed after an overnight full polysomnography

and who were willing to accept CPAP as a long-term treatment were recruited for the study. Manual titration during full polysomnography monitoring and unattended automatic titration with an automatic CPAP device (REMstar Auto) were performed. A separate cohort study of one hundred patients with OSA (AHI = 54.3 +/- 18.9 events/h) was also performed by observing the efficacy of CPAP derived from manual titration.

Results: The treatment pressure derived from automatic titration (9.8 +/- 2.2 cmH(2)O) was significantly higher than that derived from manual titration (7.3 +/- 1.5 cmH(2)O; P < 0.001) in 51 patients. The cohort study of 100 patients showed that AHI was satisfactorily decreased after CPAP treatment using a pressure derived from manual titration (54.3 +/- 18.9 events/h before treatment and 3.3 +/- 1.7 events/h after treatment; P < 0.001).

Conclusions: The results suggest that automatic titration pressure derived from REMstar Auto is usually higher than the pressure derived from manual titration.