Peers may have the potential to influence health outcomes of other patients by addressing feelings of isolation, promoting a positive outlook, and encouraging healthy behaviour [16]. A better understanding of what actually takes place in peer support interventions is needed, to tease out how peer support works, in what circumstances and for whom. This paper

synthesizes Histone Methyltransferase inhibitor qualitative research about the experiences and perceived impacts of peer support interventions across multiple chronic diseases, and in so doing, works towards a conceptual model. It also aims to identify both positive and negative aspects of peer support, and examine which experiences and perceived impacts have relevance for mentors and mentees. Given the growing interest in developing evidence based peer support interventions for people with chronic illness [17], it is important to build on what is already known. We aim to contribute to the development and implementation of future interventions. The technique of meta-ethnography was chosen for qualitative data synthesis as it is an interpretive method that preserves the qualitative Selleck DAPT nature of the material being synthesised [18]. Meta-ethnography encourages a clearer understanding of how concepts in different studies are related to each other. This mutual “translation” preserves the structure

of relationships between concepts within any given study, thereby reducing the possibility of de-contextualization [19]. The value of meta-ethnography lies not only in its ability to retain the meaning of primary data, but also in its potential to enable a higher level of analysis and generate new conceptual models. Meta-ethnography requires a literature search strategy, abstract selection, quality

appraisal, and extraction, translation, and synthesis of concepts [19]. These stages were carried out by a team of 17 researchers including two people with arthritis (one of the chronic diseases included in the synthesis). Regular face to face, tele- and video-conference meetings were held over 30 months. A customized web-based platform facilitated data extraction and analysis of the identified articles. Seven comprehensive, on-line literature Fluorouracil searches were conducted across the following disease categories: rheumatic disease, HIV/AIDS, cardiovascular disease (CVD), cancer, asthma, diabetes, and chronic disease. These diseases were identified by team consensus and by a desire to focus on physical diseases. Searched databases included MEDLINE (Ovid SP), EMBASE (Ovid SP), CINAHL (EbscoHOST), PsycINFO (Scholars Portal), ERIC (Scholars Portal), Social Sciences Citation Index (Scholars Portal), Social Work Abstracts (Scholars Portal), Cochrane Database of Systematic Reviews, The Cochrane Library (Wiley Interscience), and DARE (Centre for Reviews and Dissemination). There were no date restrictions. Studies were published in English.