Generation of ROS signaling in the cell is an inevitable consequence of the persistence of the redox cycle in your body. Formation of ROS in the cells results from two exogenous and endogenous factors. Endogenous factors include cell metabolism and energy production. In the production of energy less than 1% of the inhaled oxygen through oxidation by free radicals each Non-mitochondrial electron transport chain converted may need during the reduction of molecular oxygen to water. Exogenous cellular Ren stress include chemical agents, etc. are IR ROS w Produced during these reactions is crucial for cellular Re processes and is therefore regulated by the mechanism of the antioxidant defenses of the cell. Antioxidant components includes food, peptides, cofactors and enzymes. When the amount of generation of ROS via the normal Ma That can be counteracted by the antioxidant system is to use the cell is known, in a state of oxidative stress. ROS in the mediation statement of material Changes in the cellular Ren transmission signal is generated, tr gt For fa Is important for the survival of the cell, especially cancer cells. It is well established that the majority of cellular Ren toxicity T in cancer cells by irradiation caused the formation of free radicals, the damages caused is run on Macromolecules. ROS signaling is an important parameter in studying the effect of radiation on cancer cells. Despite the fact that cancer cells have more endogenous ROS levels compared to their normal counterparts, they are still able to survive in this Doripenem 112809-51-5 environment. This depends h With the fact that cancer cells, the signaling mechanism of ROS to manipulate to their advantage due. Cancer cells try to ROS-mediated Sch To which to escape through two main mechanisms, either by erh Increase the antioxidant capacity t of the cell by modulation elements of antioxidant defenses or increased repair capacity t of the cell. Thus, the overexpression of different redox enzymes and the induction of DNA repair via the ROS signaling, the mechanisms of acquired resistance of cancer cells is involved. One of the most important factors in the regulation of redox-sensitive transcription are involved in redox factors such as NF-kB, NRF 2, etc.
The activation and R The NF kB in cell signaling induced by radiation has already been discussed. Nrf 2 is another transcription factor activated in response to oxidative stress. It regulates many proteins, such as NADPH oxidoreductase: quinine, glutathione S-transferase, the H moxygenase, catalase and SOD. Sun targeting NRF-2 activity t in tumors resistant to radiation, k Nnte a promising strategy to circumvent radioresistance. The enzymes for maintaining the redox environment involving known, Riluzole controlled by IR-be. Therefore, it m Be possible to include that IR-mediated induction of these proteins Nrf2. Tumor concentration of cellular Ren GSH is a determinant of cytotoxicity in the t of chemotherapy and radio and an increase Increase in GSH content in cancer cells at least seems to be one of the mechanisms of acquired drug resistance of the therapy. GSH has also been shown to modulate the cytotoxicity t from a variety of chemotherapeutic agents and radiation. Therefore, the suppression of the antioxidative capacity T be used by cancer cells by inhibiting the expression of these enzymes for radiosensitization of Cance.