In 2007, HEV RNA Selleckchem GW786034 was found in 25% of pens, and 35% of 2-3 month-old pigs at the station. Three different isolates, comprising 13 sequences of HEV genotype 3e that were imported from different farms were detected. In 2010, 39% of pigs were HEV RNA positive on weeks 1, 3, or 5 of a 3-month follow-up, and 11 sequences, all representing one of the isolates that was also present in 2007, were detected. The isolate was considered to be either re-introduced to, or to persist at the station, and it was transmitted between the pigs. The study sheds light on the rate

and time of HEV transmission in swine, and describes the epidemiologic variability of HEV isolates over time. (C) 2013 Elsevier Ltd. All LY3023414 mouse rights reserved.”
“Atomic layer deposition (ALD) of Al2O3 was used to prepare metal-oxide-semiconductor (MOS) devices on two different_AlGaN/GaN heterostructures, with and without a thin GaN cap layer. Their trapping effects were evaluated by the frequency dependent conductance measurement. The trap state density decreased sharply from similar to 1 x 10(12) cm(-2) eV(-1) at the energy of 0.27 eV to similar to 3 x 10(10) cm(-2) eV(-1) at 0.45 eV. The low trap state density and exactly exponential dependence of the trap state time constant

on the gate voltage show a good quality of the gate oxide. The trap state density in the structure with a GaN cap is about 2-3 times lower than that in the structure without a cap, which might be due to the different Al2O3/GaN and Al2O3/AlGaN interface properties. The trap state density in the structures investigated is lower than those reported for the devices with the metal-organic chemical vapor deposition and Al-oxidized Al2O3 gate oxide. This shows an importance of the ALD technique for the preparation of high-performance AlGaN/GaN MOS transistors. (C) 2010

American Institute of NU7026 Physics. [doi: 10.1063/1.3428492]“
“Methods: Approximately 20 mL of CO2 were manually infused via CO2 primed injection tubing into a vein at or above the level of the antecubital fossa ipsilateral to the side of prior lead placements. Digital subtraction imaging over the axillo-subclavian region, lower neck, and mediastinum was performed. Formal interpretation was obtained from one of three interventional radiologists and at least one electrophysiologist.

Results: Significant venous occlusions were identified in five (22%) patients. Vascular access utilized for the subsequent 18 revisions performed included the imaged patent ipsilateral vein in 14 patients and the contralateral, right-sided subclavian venous system in three patients. One patient required epicardial left ventricular lead placement. There were no complications from venography.

Conclusions: Axillo-subclavian venography with gaseous CO2 in patients undergoing pacemaker or implantable cardioverter defibrillator lead revisions is feasible and safe when use of iodinated dye is contraindicated.

9 vs. 11.3) were all significantly lower for the C-1H group, p < 0.001. There were no differences between the C-1H and no induction groups at

12 months for SNX-5422 mouse overall survival 85.1% versus 93.6% p = 0.09, but freedom from significant rejection was significantly higher for the C-1H group, 84.5% versus 51.6%, p < 0.0001. In conclusion, induction therapy after CTX with C-1H results in a similar 12 month survival, but a greater freedom from rejection despite lower calcineurin levels and without the use of steroids.”
“Plant growth is impaired primarily by osmotic stress in the first phase of salt stress, whereas Na+ toxicity affects the plant growth mainly in the second phase. Salinity leads to increased Na+/K+ ratio and thus displacement of K+ by Na+ in the plant cell. Relatively higher cytosolic Na+ concentrations may have an effect on the activity of plasma membrane (PM) H+-ATPase. A decreased PM-H+-ATPase PLX4032 activity could increase the apoplastic pH. This process could limit the cell-wall extensibility and thus reduce growth according to the acid growth theory. To compare the effect of Na+ on PM H+-ATPase activity in salt-sensitive maize (Zea mays L) and salt-resistant sugar beet (Beta vulgaris L) shoot, PM vesicles were isolated from growing shoots of both species and ATPase activity was determined by assaying the P-i released by hydrolysis

of ATP. The H+ pumping activity was measured as the quenching of acridine-orange absorbance. An increased Na+/K+ ratio decreased the PM H+-ATPase activity in vesicles of maize as well as of sugar beet shoots. Nevertheless, the detrimental effect of increased Na+/K+ ratio was more severe GSK923295 datasheet in salt-sensitive maize compared to salt-resistant sugar beet. At 25 mM Na+ concentration, hydrolytic activity was not affected in sugar beet. However, a significant

decrease in hydrolytic activity was observed in maize at pH 7. In maize and sugar beet, reduction in active H+ flux was 20% and 5% at 25 mM Na+ concentration in the assay, respectively. The active H+ flux was decreased to 80% and 60%, when 100 mM K+ were substituted by 100 mM Na+. We conclude that PM H+-ATPases of salt-resistant sugar beet and maize shoot are sensitive to higher concentration of Na+. However, sugar beet PM-H+-ATPases are relatively efficient and may have constitutive resistance against lower concentration (25 mM) of Na+ as compared to that of salt-sensitive maize. (C) 2011 Elsevier Masson SAS. All rights reserved.”
“P>Ribonuclease E (RNase E) represents a key enzyme in bacterial RNA metabolism. It plays multifarious roles in RNA processing and also initiates degradation of mRNA by endonucleolytic cleavage. Plastids (chloroplasts) are derived from formerly free-living bacteria and have largely retained eubacterial gene expression mechanisms. Here we report the functional characterization of a chloroplast RNase E that is encoded by a single-copy nuclear gene in the model plant Arabidopsis thaliana.

The ears treated with erdosteine showed a diffuse inflammatory reaction and osteitis of the middle ear. Low or high concentration of intratympanic erdosteine does not offer protection against cisplatin-induced

ototoxicity as it causes a considerable inflammatory reaction.”
“Background. Cleft-lip nasal deformity (CLND) affects the overall facial appearance and attractiveness. The CLND nose shares some features in part with the aging nose.

Objectives. This questionnaire survey examined: 1) the panel perceptions of the role of secondary cleft rhinoplasty in nasal rejuvenation; and 2) the influence of a medical background in cleft care, age and gender of the panel members Selleckchem Autophagy inhibitor on the estimated age of the CLND nose.

Study design. Using a cross-sectional study design, we enrolled a random

sample of adult laypersons and health care providers. The predictor variables were secondary cleft rhinoplasty (before/after) and a medical background in cleft care (yes/no). The outcome variable was the estimated age of nose in photographs derived from 8 German nonsyndromic CLND patients. Other study variables included age, gender, and career of the assessors. Appropriate descriptive and univariate statistics were computed, and a P value of <.05 was considered to be statistically significant.

Results. The sample consisted of 507 lay volunteers and 51 medical experts (407 [72.9%] were female; mean age +/- SD = 24.9 +/- 8.2 y). The estimated age of the CLND noses was higher than their real age. The rhinoplasty decreased the estimated age to a statistically significant NU7441 price degree (P < .0001). A medical background, age, and gender of the participants were not individually associated with their votes (P > .05).

Conclusions. The results of this study suggest that CLND noses lack youthful appearance. Secondary cleft rhinoplasty rejuvenates the nose and makes it come close to the actual age of the patients. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111:174-180)”
“The effect of ginsenosides on proliferation of type A spermatogonia was investigated in 7-day-old mice. Spermatogonia

find more were characterized by c-kit expression and cell proliferation was assessed by immunocytochemical demonstration of proliferating cell nuclear antigen (PCNA). After 72-h culture, Sertoli cells formed a confluent monolayer to which numerous spermatogonial colonies attached. Spermatogonia were positive for c-kit staining and showed high proliferating activity by PCNA expression. Ginsenosides (1.0 similar to 10 mu g/ml) significantly stimulated proliferation of spermatogonia. Activation of protein kinase C (PKC) elicited proliferation of spermatogonia at 10(-8) to 10(-7) mol/L and the PKC inhibitor H(7) inhibited this effect. Likewise, ginsenosides-stimulated spermatogonial proliferation was suppressed by combined treatment of H(7).

This Review discusses the relevant bile acid receptors, the new drugs that target bile acid signalling and their possible applications.”
“Reactions of 2-benzylidenemalononitrile and 2-nitro-3-phenylacrylonitrile

CYT387 manufacturer with aryl azides in diethyl ether at room temperature gave mixtures of regioisomeric 1(3)-aryl-5-phenyl-4,5-dihydro-1(3)H-1,2,3-triazole-4,4-dicarbonitriles and 1-aryl-5(4)-phenyl-1H-1,2,3-triazole-5(4)-carbonitriles, respectively. 2-Benzylidenemalononitrile reacted with the same arylazides on heating in boiling chloroform to produce 1-aryl-2-phenylaziridine-2,2-dicarbonitriles.”
“OBJECTIVE: To estimate the long-term effects of anemia on the fetal heart by echocardiography of children who received intrauterine blood transfusions for red cell iso-immunization.

METHODS: Surviving children who received intrauterine transfusions during the period from 1992 to 2003 were

identified. Children matched for age and sex were chosen for the control group to create a 1:1 case-control study design. A clinical interview, physical examination, and echocardiography assessment (corrected for body surface area) were performed.

RESULTS: Twenty-five children were recruited for the case group and matched to 25 healthy children for the control group. Children in the case group had received a median of four intrauterine transfusion procedures (range 1-7), with a median gestation at initial intrauterine transfusion of 28 weeks (range 22-34 weeks). Hydrops was Copanlisib in vitro present in 32%. Median PARP inhibitor initial hemoglobin was 76 g/L (range 25-133 g/L). Median

gestation at delivery was 36 weeks (range 29-38 weeks). The median age of children in the case group was 10.1 years (range 3.6-15.8 years) and of those in the control group was 10.5 years (range 3.8-16.4 years; P=.122). There was no difference in body surface area, baseline heart rate, systolic blood pressure, or diastolic blood pressure between children in the case group and those in the control group. Echocardiography demonstrated three main differences: children in the case group had 9% less left atrial area (95% confidence interval [CI] 2-16% less; P=.02), 10% less ventricular mass (95% CI 1-19% less; P=.039), and an average 11 ms less mitral valve atrial duration (95% CI 3-19 ms less; P=.009) than did those in the control group. These results did not alter when adjusted for isoimmunization severity.

CONCLUSION: Fetal anemia secondary to red cell isoimmunization is associated with a reduction in left ventricular mass and left atrial area in childhood, although resting ventricular function is maintained. We speculate this may be secondary to the prenatal effects of anemia on cardiomyocyte proliferation and differentiation. (Obstet Gynecol 2010;116:851-7)”
“Excessive levels of free fatty acids are toxic to cells.

Logic behavior is reproduced by the action of regulatory factors and chemicals on the promoters and on the ribosome binding sites of biological Boolean gates. Simulations of circuits with up to four inputs show a faithful and unequivocal truth table representation, even under parametric perturbations and stochastic noise. A comparison with already implemented circuits, in addition, reveals the potential for simpler designs with the same function. Therefore, we expect the method to help both in devising new circuits and in simplifying existing solutions.”
“LePRK1

and LePRK2 are two pollen-specific receptor-like kinases from Solanum lycopersicum that are involved in signaling during pollen-pistil communication. Previously, we showed that both proteins interact in pollen and when expressed in yeast. We also showed that pollen tube buy DAPT length was regulated by phosphorylation of specific residues in the juxtamembrane ON-01910 purchase domain of LePRK2. To determine the domains responsible for the interaction between LePRK1 and LePRK2, we constructed a series of deletions, expressed them in yeast and determined their association by co-immunoprecipitation assays. We show that deletions containing extracellular domains of

LePRK1 and LePRK2 were glycosylated in yeast and were sufficient for interaction with the corresponding full-length receptor. The juxtamembrane domain of LePRK1 was sufficient for its interaction with LePRK2, Adriamycin research buy whereas LePRK2 required its kinase domain for interaction with LePRK1. These findings suggest a role for the juxtamembrane domain of LePRK2 in mediating intracellular dimerization and thus receptor kinase phosphorylation.

(C) 2012 Elsevier Masson SAS. All rights reserved.”
“The mechanisms contributing to BW gain following ovariohysterectomy in domestic cats are poorly understood. Moreover, the effects of food restriction to maintain BW following spaying have been poorly studied. Thus, our primary objective was to determine the effects of spaying and food restriction to maintain BW on adipose and skeletal muscle mRNA abundance and activity levels in cats. After a 4-wk baseline period (wk 0), 8 adult (approximately 1.5 yr old) domestic shorthair cats were spayed and fed to maintain BW for 12 wk. After 12 wk, cats were fed ad libitum for an additional 12 wk. Body composition was determined, activity levels were measured, and adipose and muscle biopsies were collected at wk 0, 12, and 24. Fasting blood samples were collected at wk 0, 6, 12, 18, and 24. To maintain BW post-spay, food intake was decreased (P < 0.05) by 30%. During this phase, mRNA abundance of adipose tissue lipoprotein lipase and leptin was decreased (P < 0.05), representing only 52 and 23% of baseline expression, respectively. Interleukin-6 mRNA, however, was increased (P < 0.05) 2-fold. Physical activity was decreased (P < 0.

METHODS: Peripheral aberrations were measured using a modified commercial Hartmann-Shack aberrometer across 42 degrees x 32 degrees of the central visual field after spherical IOL implantation and after conventional LASIK for myopia. The results were compared with those in an age-matched emmetropic group and an age-matched myopic control group, respectively.

RESULTS: The rate of quadratic change in spherical equivalent (SE) refraction, higher-order root-mean-square (RMS) aberrations, and total RMS aberrations across the visual field was greater and the amount of spherical aberration higher in the

IOL group than in the emmetropic PI3K inhibitor control group. However, coma trends were similar in the 2 groups. The rate of quadratic change in SE refraction, higher-order RMS aberrations, and total RMS aberrations was greater across the field and the amount of spherical aberration selleck chemicals higher in the LASIK group than in the myopic control group. The trend in coma across the field in the LASIK group was opposite that in the other groups.

CONCLUSIONS: Spherical IOL implantation and conventional myopic LASIK increased ocular peripheral aberrations, causing a significant increase in spherical aberration across the visual field. Laser in situ keratomileusis reversed the sign of the rate of change in coma across the

field relative to that in the other groups.”
“Phenol is released to the environment from a wide variety of industrial effluents and it causes severe problems to human health and ecosystem. In the present study, we determined that Nicotiana tabacum hairy roots (HRs) double transgenic (DT) for two peroxidase genes (tpx1 and tpx2) showed higher phenol removal efficiency than wild type (WT) HRs after 120 h of phenol treatment at the expense of endogenous

H(2)O(2). Besides, to determine whether phenol could induce oxidative stress on tobacco HRs, we analyzed the antioxidant response, superoxide anion (O(2)(center dot-)) localization and malondialdehyde (MDA) levels. Both HRs treated with phenol, showed significant increases in peroxidase (PX) activity mainly at the end of the assay PND-1186 datasheet (120 h) being PX activity from transgenic lilts 40% higher than that of WT HRs. Superoxide dismutase (SOD) and ascorbate peroxidase (APX) activities showed significant increases from 24 to 120 h of phenol treatment. PX. SOD and APX isoforms were also analyzed and slight changes were observed only in PX patterns. Both HRs showed significant differences in total glutathione (TGSH) content during treatment, being higher in DT HRs than in WT HRs. At the end of the assay, a greater accumulation of O(2)(center dot-) in different root zones was observed in WT and DT HRs. Moreover, phenol was able to increase the MDA levels in WT HRs from 48 to 120 h of the treatment, but no significant changes were observed in DT HRs.

“
“This experiment evaluated the effect of 2 levels of diet concentrate (20 and 40% of DM) and 2 levels of ruminally undegraded protein (RUP: 25 and 40% of CP) on nutrient intake, total and partial apparent nutrient check details digestibility, microbial protein synthesis, and ruminal and physiological variables. Eight Nellore heifers (233 +/- 14 kg of BW) fitted with ruminal, abomasal, and ileal cannulas were used. The animals were held in individual sheltered pens of approximately 15 m(2) and fed twice daily at 0800 and 1600 h for ad libitum intake. Heifers were allocated in two 4 x 4 Latin square designs, containing 8 heifers, 4 experimental periods, and 4 treatments in a 2 x 2 factorial arrangement. All statistical

analyses were performed using PROC MIXED of SAS. Titanium dioxide (TiO(2)) and chromic oxide (Cr(2)O(3)) were used to estimate digesta fluxes and fecal excretion. Purine derivative (PD) excretion and abomasal purine bases were used to estimate the microbial N (MN) synthesis. No significant interaction (P > 0.10) between dietary levels of RUP and concentrate was observed. There

was no effect of treatment (P = 0.24) on DMI. Both markers led to the same estimates of fecal, abomasal, and ileal DM fluxes, and digestibilities of DM and individual nutrients. Ruminal pH was affected by sampling time (P < 0.001), but no interaction between treatment and sampling time was observed (P = 0.71). There was an interaction between treatment and sampling time (P < 0.001) for ruminal NH(3)-N concentration. A linear decrease (P = 0.04) over sampling time was observed for the higher level of AZD8186 RUP, whereas a quadratic effect (P < 0.001) of sampling time was observed for the lower level of RUP. The higher level of dietary concentrate led to greater MN yield regardless of the level of RUP. The MN yield and the efficiency of microbial yield estimated from urinary PD excretion produced greater BYL719 research buy (P < 0.01) values than those estimated by either TiO(2) or Cr(2)O(3),

which did not differ (P = 0.63) from each other. However, all methods yielded values that were within the range reported in the literature. In conclusion, no interactions between dietary levels of RUP and concentrate were observed for ruminal and digestive parameters. Neither RUP nor concentrate level affected DMI. Titanium dioxide showed to be similar to Cr(2)O(3) as an external marker to measure digestibility and nutrient fluxes in cattle.”
“An experimental investigation of the initial heating rate of 50 nm ferromagnetic nanoparticles (Fe(3)O(4)) suspended in water and incorporated in an agar gel was conducted to study the thermal heating effects resulting from Brownian motion and hysteresis losses. Particles were placed in an alternating current magnetic field with intensities of 28.6, 35.8, 38.9, and 43.0 kA m(-1), at frequencies ranging from 161 to 284 kHz.

An analysis of variability in execution using this function to quantify performance at the level of results offers substantially less sensitivity to coordinates than analysis of a covariance matrix of execution variables. This is an initial step towards developing coordinate-invariant analysis methods for movement neuroscience.”
“In this paper, we investigate the influence of electrode roughness on the leakage current

in TiN/high-kappa ZrO2/TiN (TZT) thin-film capacitors which are used in dynamic random access memory cells. Based on a microscopic transport model, which is expanded to incorporate electrode roughness, we assess the ultimate scaling potential of TZT capacitors in terms of equivalent oxide thickness, film smoothness, thickness VX-809 datasheet fluctuations, defect density and distribution, and conduction band offset (CBO). The model is based on three-dimensional, https://www.selleckchem.com/products/Staurosporine.html fully self-consistent, kinetic Monte Carlo transport simulations. Tunneling transport in the bandgap of the dielectric is treated,

which includes defect-assisted transport mechanisms. Electrode roughness is described in the framework of fractal geometry. While the short-range roughness of the electrodes is found not to influence significantly the leakage current, thickness fluctuations of the dielectric have a major impact. For thinner dielectric films they cause a transformation of the dominant transport mechanism from Poole-Frenkel conduction Transmembrane Transporters inhibitor to trap-assisted tunneling. Consequently, the sensitivity of the leakage current on electrode roughness drastically increases on downscaling. Based on the simulations, optimization of the CBO is suggested as the most viable strategy to extend the scalability of TZT capacitors over the next chip generations. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3531538]“
“Quinacrine is one of the few molecules tested to treat patients affected by prion diseases, although the clinical outcome is largely unsatisfactory.

To identify novel derivatives with higher neuroprotective activity, we evaluated the effects of a small library of acridine derivatives. The 6-chloro-2-methoxyacridine derivatives bearing on position 9 a quinolizidin-1-ylamino (Q1, Q2) or a quinolizidin-1-ylalkylamino residue (Q3, Q4, Q6, Q7), the thio-bioisoster of Q3 (Q5), the 9-(N-lupinylthiopropyl)amino derivative (Q8) and simple acridines (Q9 and Q10) were considered. We compared the effects of quinacrine and these novel analogues in the inhibition of the cytotoxic activity and protease K (PK) resistance of the human prion protein fragment 90-231 (hPrP90-231). We demonstrate that quinacrine caused a significant reduction of hPrP90-231 toxicity due to its binding to the fragment and the prevention of its conversion in a toxic isoform.

Studies of photoluminescence in the InGaN:Mg layers exhibit band-to-band radiative recombination which has created much controversy. The most important feature of samples grown at temperatures 860 degrees C and below, is a green band observed in InGaN:Mg layers (not in GaN:Mg obtained at the same T(gr)) dominating the whole spectrum at room temperature. Its maximum shifts from 2.5 to 2.2 eV with increasing x up to 0.13. Presence of this band was previously reported for InGaN:Mg. We present arguments

that it originates from deep donor level. (C) 2010 American Institute of Physics. [doi:10.1063/1.3466768]“
“Changes in antioxidant systems in soybean [Glycine max (L) Merr., Fabaceae] genotypes check details infected with Sclerotinia sclerotiorum were studied 12, 24, 48 and 72 h after inoculation. Generation of superoxide and hydroxyl radicals was evaluated together with the production of malonyldialdehyde, main end product of lipid peroxidation. Several enzymatic and non-enzymatic parameters were monitored as well, such as the activity of antioxidant enzymes superoxide dismutase

and pyrogallol and guaiacol peroxidases, reduced glutathione, soluble proteins and total carotenoids content. Results showed that genotypes expressed oxidative burst as well as different antioxidant systems in response to biotic stress caused by pathogen invasion. It has been confirmed that, although hypersensitive cell death is efficient against biotrophic selleck pathogens, https://www.selleckchem.com/EGFR(HER).html it does not protect soybean plants against infection by the necrotrophic

pathogen such as S. sclerotiorum. Still, some genotypes showed distinctive and combined activity of several biochemical parameters which may point to further directions in exploring host-pathogen relations and lead to selection and production of new genotypes with higher levels of tolerance (C) 2010 Elsevier Masson SAS. All rights reserved.”
“Uneventful myopic laser in situ keratomileusis (LASIK) was performed in both eyes of a 33-year-old woman. Two weeks after LASIK, examination of the left eye revealed flap striae radiating inferonasally from the superior hinge. The flap was relifted and repositioned to remove the irregular astigmatism and reduce the striae. Before the flap was relifted, Fourier-domain optical coherence tomography (FD-OCT) showed the gap at the temporal flap, which had not been detected by biomicroscopy. After the flap was relifted, FD-OCT documented that the gap was closed. High-resolution FD-OCT was helpful in the visualization and management of flap displacement.”
“We report on the proof of photovoltaic activity of homojunction ZnTe solar cells in which n-ZnTe layers are fabricated by thermal diffusion of Al into p-ZnTe at several diffusion times to control the junction depth. An open circuit voltage of approximately 0.9 V was obtained under 1 X sun AM 1.

Intravesical LPs treatment is safe and its efficacy has sustained duration. Furthermore large-scale, placebo-controlled studies BVD-523 are warranted to assess the efficacy for this promising new treatment for IC/PBS. Copyright (C) 2011, Elsevier Taiwan LLC. All rights reserved.”
“Objective. The objective of this study was to provide evidence that the magnitude of angiogenesis induced by oral mucosa epithelium with potentially malignant lesions is related to the degree of epithelial aggressiveness.

Methods and results. We evaluated 96 biopsies that included: (1) leukoplakia with and without dysplasia, (2) nontumoral borders adjacent to squamous cell carcinomas with and without dysplasia, and (3) normal

oral mucosa. Number, size, and localization of vessels labeled immunohistochemically for the antigen CD34 were assessed by image analysis using a software developed “”ad hoc.”" All vascular sections and those localized immediately below the epithelium (sub-basal vessels) were separately evaluated in areas 30-mu m deep. Vascular endothelial growth factor (VEGF) expression was labeled immunohistochemically PP2 chemical structure and evaluated semiquantitatively against a standard. Leukoplakia and nontumoral borders adjacent to carcinomas exhibited an increase in VEGF expression and in subepithelial

vascularization. This increase was significantly greater in leukoplakia with dysplastic changes than in leukoplakia without dysplasia. Conversely, no differences were observed between epithelia with and without dysplasia adjacent to carcinomas.

Conclusions. Demonstration of expression of epithelial VEGF and sub-basal vascularization could

be an additional aid for evaluation of the severity of potentially malignant lesions in oral mucosa routine biopsies. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111:486-493)”
“The aim of this study is to evaluate the efficacy and the safety of the holmium:YAG laser for intravesical mesh excision in female patients with urinary bladder erosion complicated tension-free vaginal tape (TVT) procedure.

Between June 2, 2008 and December 31, 2009, seven patients who underwent laser excision of an intravesically protruding tape were followed up every 3 months for a total period of 1 year by disease-specific questionnaires, physical examination, cough stress test, PD-1/PD-L1 inhibitor urine analysis, urine bacterial culture, ultrasound and uroflowmetry. Filling cystometry was offered preoperatively and at the 3rd month, while cystoscopy was offered preoperatively and at the 1st month. The presenting symptoms were dysuria, urgency, hematuria, and recurrent lower urinary tract infections. Holmium laser was used for ablation and removal of the tape. The postoperative period was uneventful.

There was a substantial improvement in the urgency status, in the maximum flow rate (Q (max)) from 11.29 ml/s to 19.43 ml/s, in the voided volume (VV) from 185 ml to 251.43 ml and in the maximum cystometric capacity (C) from 237.86 ml to 310.