Subjective written questionnaire also showed elevated symptoms of driving fatigue. They proposed using HRV as a quantitative index for driving fatigue. Li et al. [13�C14] further studied the effect of acupuncture on driving fatigue. Their findings suggested that driving fatigue induced symptoms Tubacin MM could be attenuated by acupuncture.In this study, we monitored multiple physiological parameters, including palm temperatures (left and right), HR, BP (SYS/DIA), and HRV parameters before and after an indoor driving task lasting for 120 minutes. Volunteers were divided into two groups. One group conducted the driving task continuously while the other group had a 15-min exercise break taken at mid-term (60-min from start) of driving. By comparing the physiological changes between the two groups, the effect of exercise break on driving fatigue could be investigated.
In addition, a written questionnaire was filled by each participant before and after the driving task to gauge the subjective feeling of driving fatigue. It is our expectation that the results of this series of studies (including Liang et al.  that was published earlier) could provide useful information for the quantitative definition Inhibitors,Modulators,Libraries of driving fatigue based upon physiological parameter changes. Identification of key parameters for Inhibitors,Modulators,Libraries monitoring driving fatigue is the next goal for these studies. This is a prerequisite step in the development of driving fatigue preventive devices.2.?Materials and MethodsAn indoor simulated driving test (instead of a road driving test) was selected in consideration of cost, safety, and control of variables.
2.1. SubjectsIn order to avoid gender Inhibitors,Modulators,Libraries and age influences on HRV [16�C17], a total of 40 male subjects within a tight age range (22.6 �� 1.6 years old; see Table 1; all college or graduate school students) were recruited to take the driving test. All subjects Inhibitors,Modulators,Libraries were currently healthy and not under
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